Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05771077 |
Other study ID # |
Asmaa Khater |
Secondary ID |
|
Status |
Completed |
Phase |
Phase 1
|
First received |
|
Last updated |
|
Start date |
June 1, 2022 |
Est. completion date |
December 15, 2022 |
Study information
Verified date |
March 2023 |
Source |
Egymedicalpedia |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
Dental caries is a common oral disease. The process of caries formation is a cycle of
remineralization and demineralization with various stages being either reversible or
irreversible.
Description:
White spot lesions (WSLs) are defined as enamel surface and subsurface demineralization,
without cavitation. These manifestations represent the first clinical observation of the
progression of dental caries, with the possibility of being reversed.
WSLs are characterized by a white, chalky, opaque appearance and are commonly located in
pits, fissures, and smooth surfaces of teeth. However, after the placement of fixed
orthodontic appliances, there are an increasing number of plaque retention sites due to the
presence of brackets, bands, wires and other applications, which make oral hygiene more
difficult, and limit naturally occurring self-cleansing mechanisms. As a consequence, there
is an increased risk of demineralization and, conclusively, of WSLs forming on smooth
surfaces, if there is no effective plaque removal
The clinical characteristics of these lesions include loss of normal translucency of the
enamel because of altered light properties with a chalky white appearance, particularly when
dehydrated; a fragile surface layer susceptible to damage from probing, particularly in pits
and fissures; increased porosity, particularly of the subsurface, with increased potential
for uptake of stains; reduced density of the subsurface, which may be detectable
radiographically, with transillumination or with modern laser detecting devices; and
potential for remineralization, with an increased resistance to further acid challenge
particularly with the use of enhanced remineralization treatments.
It is possible to find numerous therapies for WSLs, for instance, hygiene education,
fluorides, phosphopeptide compounds, xylitol and infiltrative resins, microabrasion and/or
bleaching, and preparation and restoration. The professional application or prescription of
fluorides for home use includes: gels, toothpastes, mouthwashes and varnishes. The fluoride
ions are revealed in three ways: sodium monofluorophosphate, sodium fluoride and amine
fluoride. It has been found that high fluoride concentrations promote WSL remineralization
However; it occurs in the enamel surface and inhibits the ions' movement through the
subsurface, affecting the subsurface remineralization and therefore, the light reflection