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NCT05001035 Clinical Trial

Effect of Different Biomimetic Materials on White Spot Lesions in Enamel

White Spot Lesion Clinical Trial

Official title:
Effect of Different Biomimetic Materials on White Spot Lesions in Enamel

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05001035
Other study ID # OP-P-018-001
Secondary ID OPDEN-107-1-G
Status Completed
Phase N/A
First received
Last updated
Start date July 1, 2021
Est. completion date September 20, 2021

Study information
Verified date October 2021
Source Benha University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study will be conducted to evaluate: 1- The remineralizing effect of different biomimetic materials (Zinc carbonate hydroxyapatite nanoparticles, Poly-amido amine (PAMAM) and bioactive glass nanoparticles) on white spot lesions in enamel. 2- The clinical efficacy of these agents on disappearance of these white spots.

Recruitment information / eligibility
Status Completed
Enrollment 21
Est. completion date September 20, 2021
Est. primary completion date September 18, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 15 Years to 25 Years
Eligibility Inclusion Criteria: - Total of 21 patients enrolled in this study will be selected having at least 4 teeth (one on each quadrant) which will be extracted for orthodontic treatment. - These patients will be selected according to age groups between 15-25 years old - good oral hygiene - free of destroying habits for dental tissues Exclusion Criteria: - Bruxism - soft drinks consumption - acid regurgitation, etc.). - Selected teeth having any cracks, malformations, dysplasia or caries.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Time of assessment
Immediate and after one month and after two months

Locations
Country Name City State
Egypt Faculty of dental medicine for girls branch of Alazhar University Cairo

Sponsors (1)
Lead Sponsor Collaborator
Benha University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary change in remineralization from base line to time limit Change in its density in digital xray Immediate and one month and two months
Primary changes of appearance from base line photograph to time limit White spots disappear on digital photography Immediate and one month and two months
See also
  Status Clinical Trial Phase
Completed NCT05710874 - A Prospective, Randomized, Clinical Study on the Effects of CPP-ACP-paste, Fluoride and a Combination on the Evolution of White Spot Lesions in Orthodontic Patients After Debonding. N/A
Completed NCT04107012 - Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment N/A
Active, not recruiting NCT04342858 - Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment Phase 2
Recruiting NCT05989750 - Air-polishing With Erythritol During Orthodontic Tretament N/A
Completed NCT06200129 - İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin N/A
Not yet recruiting NCT03976583 - Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions Phase 2
Not yet recruiting NCT06051981 - White Spot Lesions Treatment in Orthodontic Phase 4
Not yet recruiting NCT04422860 - Remineralization Efficacy of Gum Arabic Varnish. Phase 2/Phase 3
Completed NCT04560478 - Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients N/A
Completed NCT02027922 - Clinical Effectiveness of Various Professionally Applied Fluoride Prophylaxes in Groups at High Risk N/A
Completed NCT04908293 - Home Remineralization of White Spot Lesions With Two Different Toothpastes. N/A
Not yet recruiting NCT05868603 - Effect of Different Remineralization Gels N/A
Not yet recruiting NCT06331442 - The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients N/A
Not yet recruiting NCT05306691 - Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients Early Phase 1
Active, not recruiting NCT06166849 - Clinical Evaluation of an Experimental Remineralization Product N/A
Completed NCT05775250 - Evaluation of Two Varnishes on the Improvement of White Spot Lesions in Children N/A
Not yet recruiting NCT06358066 - The Remineralization of Early Enamel Caries in Permanent Teeth Phase 1
Completed NCT03114475 - Effect of CO2 Laser on Enamel White Spot Lesion Formation Around Orthodontic Brackets N/A
Active, not recruiting NCT06403371 - The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients N/A
Completed NCT05771077 - Effect of Poly Amido Amine Dendrimer, Nano-hydroxyapatite Phase 1