White Spot Lesion Clinical Trial
Official title:
THE EFFICACY OF MI VARNISH VERSUS PRO SEAL SEALANT ON PREVENTION OF WHITE SPOT LESIONS IN ORTHODONTIC PATIENTS: A RANDOMIZED CLINICAL TRIAL
The purpose of the study is o compare the efficacy of CPP-ACP MI Varnish and ProSeal sealant in preventing white spot lesion (WSL) formation in orthodontic patients.
This prospective randomized clinical trial included 40 orthodontic patients between the ages of 12-17 who were randomly allocated to two groups. Group 1 (Sealant Group) received sealant on the maxillary anterior canines, lateral incisors, and central incisors, with reapplication of the sealant every 3 months. Group 2 (Varnish Group) had MI Varnish applied every 4-6 weeks, without sealant placed on the maxillary anterior teeth. White spot lesion formation was evaluated with standardized digital photographs at two timepoints, T1 (initial appointment before bonding), and T2 (12 months later, with brackets removed). The brackets were removed in order to facilitate an adequate photographic exam. Photographs were analyzed side-by-side at the conclusion of the study with the Enamel Decalcification Index (EDI). The location of WSLs were recorded by tooth type and by region. Oral hygiene was evaluated at T1 and T2. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05710874 -
A Prospective, Randomized, Clinical Study on the Effects of CPP-ACP-paste, Fluoride and a Combination on the Evolution of White Spot Lesions in Orthodontic Patients After Debonding.
|
N/A | |
| Completed |
NCT04107012 -
Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment
|
N/A | |
| Active, not recruiting |
NCT04342858 -
Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment
|
Phase 2 | |
| Recruiting |
NCT05989750 -
Air-polishing With Erythritol During Orthodontic Tretament
|
N/A | |
| Completed |
NCT06200129 -
İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin
|
N/A | |
| Not yet recruiting |
NCT03976583 -
Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions
|
Phase 2 | |
| Not yet recruiting |
NCT06051981 -
White Spot Lesions Treatment in Orthodontic
|
Phase 4 | |
| Not yet recruiting |
NCT04422860 -
Remineralization Efficacy of Gum Arabic Varnish.
|
Phase 2/Phase 3 | |
| Completed |
NCT02027922 -
Clinical Effectiveness of Various Professionally Applied Fluoride Prophylaxes in Groups at High Risk
|
N/A | |
| Completed |
NCT04908293 -
Home Remineralization of White Spot Lesions With Two Different Toothpastes.
|
N/A | |
| Not yet recruiting |
NCT05868603 -
Effect of Different Remineralization Gels
|
N/A | |
| Not yet recruiting |
NCT06331442 -
The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients
|
N/A | |
| Not yet recruiting |
NCT05306691 -
Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients
|
Early Phase 1 | |
| Active, not recruiting |
NCT06166849 -
Clinical Evaluation of an Experimental Remineralization Product
|
N/A | |
| Completed |
NCT05775250 -
Evaluation of Two Varnishes on the Improvement of White Spot Lesions in Children
|
N/A | |
| Not yet recruiting |
NCT06358066 -
The Remineralization of Early Enamel Caries in Permanent Teeth
|
Phase 1 | |
| Completed |
NCT03114475 -
Effect of CO2 Laser on Enamel White Spot Lesion Formation Around Orthodontic Brackets
|
N/A | |
| Active, not recruiting |
NCT06403371 -
The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients
|
N/A | |
| Completed |
NCT05771077 -
Effect of Poly Amido Amine Dendrimer, Nano-hydroxyapatite
|
Phase 1 | |
| Completed |
NCT05721586 -
Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth
|
N/A |