White Spot Lesion Clinical Trial
Official title:
Evaluation of Enamel Resistance to White Spot Lesion Formation Around Orthodontic Brackets After CO2 Laser Irradiation: A Randomized Controlled Clinical Trial
This study aims to evaluate the clinical effect of CO2 laser on enamel resistance to white
spot lesions formation around orthodontic brackets.
25 patients needing fixed orthodontic treatment will participate in the study, the CO2 laser
will be applied in a split mouth design around orthodontic brackets in two contrast quarters
of mouth in every patient and the other quarters will serve as a control. The white spot
lesion formation will be monitored around the brackets during the orthodontic treatment after
four and twelve weeks of irradiation with laser.
Prior to enrollment of each subject into the study, they will be examined completely to
determine the orthodontic treatment plan. The operator will inform them about the aim of the
study and ask them to provide a written informed consent.
Before brackets' bonding (T0) the operator will evaluate with intraoral clinical examination
and take intraoral photographs and evaluate with DIAGNOdent. Then after brackets' placement
on teeth, the CO2 laser will be applied to the area of enamel about 2 mm of width around
orthodontic brackets in a split mouth design. To blind the intervention sides on patients the
control sides will receive nontherapeutic light.
Then intraoral photographs will be taken and the teeth will be assessed with DIAGNOdent (T1).
All patients will be trained to brush their teeth with a tooth paste containing 1100 ppm of
fluoride twice a day. After 4 weeks of irradiation (T2) the patients will be examined for
white spot lesions formation by clinical examination using Geiger index, photographic
examination using AutoCAD 2009 evaluating formation and area percentage of white spot
lesions, and the degree of demineralization will be assessed with DIAGNOdent. The all exams
will also be done after 12 weeks of irradiation (T3).
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