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White Spot Lesion clinical trials

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NCT ID: NCT06358066 Not yet recruiting - White Spot Lesion Clinical Trials

The Remineralization of Early Enamel Caries in Permanent Teeth

Start date: June 6, 2024
Phase: Phase 1
Study type: Interventional

Evaluate clinically the remineralizing potential of self-assembling peptide ( P11-4) fluoride plus in early enamel carious lesions of permanent anterior teeth.

NCT ID: NCT06331442 Not yet recruiting - White Spot Lesion Clinical Trials

The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients

Start date: May 2024
Phase: N/A
Study type: Interventional

This randomized controlled trial will be conducted on 40 orthodontic patients at the Department of Orthodontics, University Hospital Centre Zagreb, Croatia. Respondents will be randomly allocated into 4 groups (n=10). The first group will receive photodynamic therapy, the second tricalcium phosphate varnish with 5% NaF (sodium fluoride), the third 1% chlorhexidine varnish, while the fourth group will be the negative control. Before and after the mentioned interventions, the participants will have the amount of plaque measured using the plaque index and the bacteriological composition of the plaque assessed using the mass spectrometry and PCR. The gingival condition will be assessed using the gingival index. Also, the occurrence of white spot lesions will be evaluated on intraoral photographs.

NCT ID: NCT06051981 Not yet recruiting - White Spot Lesion Clinical Trials

White Spot Lesions Treatment in Orthodontic

WSL
Start date: October 2023
Phase: Phase 4
Study type: Interventional

The study aims to investigate the effectiveness of a new treatment for demineralized white spot lesions (WSLs) after fixed appliance therapy. The trial will consist of four parallel groups: control, Fluoride Varnish (FV), Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP), and Resin Infiltration (RI) groups. Patients will be recruited from Riyadh Elm University's electronic record system and contacted by phone. They will be given an appointment to visit the dental clinic. A total of 22 patients with WSLs will be selected for the study. Two examiners will perform dental examinations using a dental mirror and a ball-ended probe to code the WSL against the ICDAS system. The level of agreement between the two examiners will be assessed using reliability analysis, with an agreement level of above 80% considered. Buccal WSLs will be defined as those that extend from the center of the buccal to either the mesial or distal surface. WSLs coded 3 or higher will be excluded from further examination and treated accordingly.

NCT ID: NCT05868603 Not yet recruiting - White Spot Lesion Clinical Trials

Effect of Different Remineralization Gels

Start date: May 24, 2023
Phase: N/A
Study type: Interventional

The aim of the study is to treat white spot lesions that occur after orthodontic treatment. Different gels will be used for remineralization. The study will consist of 45 people between the ages of 15-18. 45 people will be divided into 3 groups.

NCT ID: NCT05584878 Not yet recruiting - White Spot Lesion Clinical Trials

Remineralizing Potential of Biomimetic Scaffolds on Enamel White Spot Lesions

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

The modern concept in caries treatment focuses on the non-invasive approach and on the biomimetic remineralization of early non-cavitated white spot carious lesions. Recently developed biomimetic scaffolds attempt to remineralize the dental tissues and are more regenerative than reparative.

NCT ID: NCT05306691 Not yet recruiting - White Spot Lesion Clinical Trials

Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients

Start date: May 15, 2022
Phase: Early Phase 1
Study type: Interventional

To evaluate the remineralizing capability of biosmart S-PRG barrier coat varnish and its employment in clinical practice

NCT ID: NCT04673097 Not yet recruiting - White Spot Lesion Clinical Trials

Performance of Different Resin Infiltration Materials on White Spot Lesions: Clinical and Laboratory Assessments

Start date: December 19, 2020
Phase: N/A
Study type: Interventional

The study is a clinical controlled trial. Ethical approval will be obtained from Imam Abdulrahman bin Faisal University, Dammam. The study participants will be recruited from the dental hospital and conducted between November 2020 to November 2020. This will be a single-center, randomized, single blinded with a 1:1:1 allocation ratio for the application of Icon® resin infiltration, MI Paste Plus and both treatments

NCT ID: NCT04422860 Not yet recruiting - Caries,Dental Clinical Trials

Remineralization Efficacy of Gum Arabic Varnish.

Start date: October 2020
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to evaluate the remineralizing capacity of Gum Arabic varnish and its implementation into clinical practice.

NCT ID: NCT04245787 Not yet recruiting - White Spot Lesion Clinical Trials

Remineralization Potential of Curodont Repair Flouride Plus Versus CPP-ACP in Management of White Spot Lesions: Randomized Clinical Trial

Start date: February 2020
Phase: N/A
Study type: Interventional

The goal of modern dentistry is to manage non-cavitated caries lesions non- invasively through re-mineralization process to prevent the disease progression and improve aesthetics, strength, and function. Re-mineralization is defined as the process that supplies calcium, phosphate and flouride ions from an external source to the tooth to convert ion deposition into crystal voids in demineralized enamel. White spot lesions should be managed using a multifactorial approach. The most important strategy is to prevent demineralization and biofilm formationand use of methodologies for remineralization of lesions . Self-assembling peptide (P11-4) has shown great potential for natural repair of early caries lesions through emerging biomimetic re-mineralization properties. (Takahashi Fet al in 2015) This peptide forms a 3D matrix within demineralized carious lesions areas, which enables novo hydroxyapatite crystal formation facilitating the so-called guided enamel regeneration of the lost enamel structure. The peptide has shown encouraging results as a scaffold for enamel regeneration

NCT ID: NCT04017884 Not yet recruiting - White Spot Lesion Clinical Trials

Evaluation of Remin Pro Forte Versus Remin Pro on Treatment of White Spot Lesions Post Orthodontic Treatment

Start date: July 1, 2020
Phase: N/A
Study type: Interventional

randomized clinical trial to evaluate caries regression, the change in colour and mineral content of the demineralized enamel after treatment with Remin Pro Forte paste (fluoride, hydroxyapatite, xylitol, ginger, and curcuma) and Remin pro cream which contains (fluoride, hydroxyapatite, xylitol) remineralizing agents with the null hypothesis that Remin Pro forte will have the same clinical performance as Remin Pro in remineralizing white spot lesions post-orthodontic treatment.