Whipple Disease Clinical Trial
Official title:
Detection and Characteristic of Whipple Diseases in the Great Britany
Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma
wipplei on a genetic predisposition which should be considered in patients with recurrent
episodes of seronegative arthritis, erosive or not, or inflammatory low back pain, chronic
diarrhea, persistent fever, unexplained neurological signs, uveitis, endocarditis, and
epithelioid granuloma.
Laboratory tests may show malabsorption, erythrocyte sedimentation rate and C-reactive
protein elevation, anemia, thrombocytosis, eosinophilia and lymphopenia.
None of theses findings is specific and most patients have arthritis or low back pain
mimicking rheumatoid arthritis and spondyloarthritis.
As the disease is rare, chance for positive polymerase chain reaction testing for Tropheryma
whipplei is low in this context.
n/a