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Wheeze clinical trials

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NCT ID: NCT02743663 Completed - Asthma Clinical Trials

The Development of Novel Clinical Tests to Diagnose and Monitor Asthma in Preschool Children

WheezyER
Start date: June 2014
Phase:
Study type: Observational

The study will ascertain the ability of preschool lung function tests to distinguish healthy children from those with wheeze, and to differentiate phenotypes of wheezy children (high and low risk for asthma as defined by API) in order to predict response to therapy, and to explore the correlation between preschool lung function test results and symptoms, in order to develop objective methods for monitoring asthma.

NCT ID: NCT02496468 Recruiting - Asthma Clinical Trials

Pediatric Arm of DZL All Age Asthma Cohort

ALLIANCE
Start date: January 2013
Phase:
Study type: Observational

Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).

NCT ID: NCT02319564 Withdrawn - Wheeze Clinical Trials

Combined Glucocorticoid Adrenergic Therapy For Wheezy Preschool Children

CONjuGATE
Start date: April 2016
Phase: Phase 4
Study type: Interventional

The investigators goal is to conduct a pilot randomized controlled trial (RCT) whose purpose is to determine the feasibility of a randomized trial designed to determine if either inhaled beclomethasone or a combination of inhaled beclomethasone/salbutamol (Clenil Compositum) are superior to placebo in treating pre-school aged children with an acute wheezing episode.

NCT ID: NCT01868932 Withdrawn - Wheeze Clinical Trials

Treating Wheezing in Children With Hypertonic Saline (TWICS)

TWICS
Start date: October 2013
Phase: Phase 2
Study type: Interventional

Hypothesis: substitution of nebulized 3% NaCl (HS) for the standard normal saline (NS) used in bronchodilator therapy for acute viral wheezing in all children under age 6 years will provide superior symptom relief leading to decreased admission rates from the Emergency Department. The study will test the efficacy of frequent doses of inhaled bronchodilator co-administered with either 3% hypertonic saline (HS, study group) or 0.9% normal saline (NS, control group) in a prospective, double blind, randomized controlled, multi-centre clinical trial of children under age 6 years presenting to the ED with acute viral-associated wheezing.