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Clinical Trial Summary

The purpose of this study is to determine if ChimeriVax West Nile vaccine is safe and effective in preventing West Nile disease in adults over 50 years of age.


Clinical Trial Description

Currently, the only method of prevention of West Nile infection is control of the mosquito vectors associated or avoidance of mosquito bites, which has proven largely ineffective. Developing a safe, effective vaccine and making it widely available will enhance the prospects of prevention and control of this disease. In addition, natural infections with the YF virus and WN virus are more severe in the elderly. Therefore, a study among healthy older subjects or those with well controlled chronic diseases will provide data to determine a ChimeriVax-WN02 vaccine dose that is immunogenic and well tolerated. ;


Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention


Related Conditions & MeSH terms


NCT number NCT00746798
Study type Interventional
Source Sanofi
Contact
Status Completed
Phase Phase 2
Start date October 2008
Completion date December 2009

See also
  Status Clinical Trial Phase
Withdrawn NCT04371003 - Prospective Investigation of Oxidative Stress in West Nile Virus Infection
Terminated NCT00091845 - An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Phase 1
Terminated NCT00927953 - Treatment of West Nile Virus With MGAWN1 Phase 2
Completed NCT00300417 - Phase I Study of West Nile Virus Vaccine Phase 1
Completed NCT00106769 - Vaccine to Prevent West Nile Virus Disease Phase 1
Completed NCT00537147 - Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Phase 1
Completed NCT00442169 - Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Phase 2