Comparison of Body Weight Change Through Different Smeglutide Administration Methods

Weight Change, Body Clinical Trial

Official title: Prospective Randomized Controlled Study on the Improvement of Body Weight Among Overweight and Obese Patients Through Different Smeglutide Administration Methods

Status Not yet recruiting

Clinical Trial Summary

Investigators determined to detect the effect of smeglutide on body weight and metabolic indexes among overweight and obese participants through two different dosing programs.

Clinical Trial Description

Participants will be randomized into either group. One group will start from 0.25mg per week for four weeks, then increase to 0.5mg per week for four weeks, and 1mg per week maintenance dose for 8 weeks. The other group dosage regime depends on the tolerance of the semaglutide from participants. The dosage will stabilize on the dose how much participant could tolerate. At the end of 16 weeks treatment, comparison will be carried out on weight change before and after treatment and (1) Comparison of different administration methods (standards and titrations) on participant compliance, appetite and quality of life improvement; (2) Comparison of metabolism (waist hip circumference, body fat and body composition, blood pressure, blood lipid, blood glucose, insulin resistance) in different administration modes; (3) Comparison of adverse reactions of metabolic drugs in different administration modes. ;

Related Conditions & MeSH terms

• Body Weight
• Body Weight Changes
• Weight Change, Body

• NCT number: NCT05616052
• Study type: Interventional
• Source: Huashan Hospital
• Contact: xiaolong zhao
• Phone: 86-13501827230
• Email: xiaolongzhao@163.com
• Status: Not yet recruiting
• Phase: Phase 4
• Start date: December 1, 2022
• Completion date: December 1, 2023