Critical Care Clinical Trial
Official title:
Cardiorespiratory Changes in Patients Being Weaned Off Mechanical Ventilation: a Randomized Crossover Clinical Trial
The objective of this study was to analyze changes in cardiac function using Doppler echocardiogram in critical patients during weaning from mechanical ventilation using two different weaning methods (pressure support and T-tube) and to compare a subgroup of patients: success vs. failure in weaning and patients with vs. without heart disease.
Weaning from mechanical ventilation (MV) involves physiological changes that can overload
the cardiorespiratory system due to changes in the interaction between patient and
ventilator.
This was a randomized crossover clinical trial that included patients in an intensive care
unit (ICU) who had been on MV for more than 48 hours and who were considered ready for
weaning. Cardiorespiratory variables, oxygenation, electrocardiogram (ECG) and Doppler
echocardiogram findings were analyzed at baseline and after 30 minutes in each trial weaning
method (PSV and T-tube). Comparisons were made between PSV and T-tube, weaning success and
failure and patients with and without heart disease, using ANOVA and Student's t test. The
level of significance was set at p < 0.05.
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