High-risk for Reintubation Patients Clinical Trial
Official title:
The Effectiveness of Inspiratory Muscle Training and Nasal High Flow Oxygen in Difficult Weaning of ICU Patients
The purpose of the present study is to investigate the effectiveness of inspiratory muscle training and nasal high flow oxygen in patients with difficult weaning and high-risk for re-intubation. The hypothesis of the study is that starting inspiratory muscle training once patients are awake and co-operative along with the application of nasal high flow oxygen immediately after extubation will have a beneficial effect in preventive re-intubation in these high-risk patients.
20-30% of intubated patients are difficult to be weaned off the mechanical ventilation and
have a prolonged ICU stay. It is well established that prolonged ICU stay is associated with
reduced muscle strength, functional ability and quality of life.
Inspiratory muscle training (IMT) via a threshold device has been proposed as an effective
exercise for minimizing the detrimental effect of mechanical ventilation in critical ill
patients with prolonged weaning. Additionally, Nasal High Flow (NHF) oxygen has been proved
to support efficiently either high or low-risk patients after extubation and thus preventing
re-intubation.
A randomized intervention study was designed to assess the efficacy of combining IMT and NHF
as therapeutic strategies for difficult weaning. Once patients with prognostic factors of
difficult weaning are awake and co-operative they will be randomized to one of the two
following study groups: 1) IMT and NHF group, 2) IMT and Venturi mask group. IMT will start
as soon as the patient wakes up and is cooperative, ventilated with support settings. Each
allocated oxygen delivery device will be applied immediately after extubation. IMT
intervention will continue until patients' discharge from the ICU.
;