Weaning Failure Clinical Trial
Official title:
The Effect of Doxapram Versus Theophylline on Diaphragmatic Function and Weaning From Mechanical Ventilation After Open Heart Surgery
Doxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect
and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous
oxide or benzodiazepines over dosage.
Value of theophylline to stimulate the respiratory neuronal network has been examined by
previous studies and increases the activity of respiratory muscles, including the intercostal
, transversus abdominis muscles and the diaphragm, it also has bronchodilator and
anti-inflammatory effects.
This randomized comparative study will be conducted in the post-surgical cardio-thoracic intensive care unit in Beni -Suef University Hospital after approval of the department of anesthesiology, surgical ICU and pain management , and cardio thoracic department and the local ethics and research committee, and obtaining written informed consents from the patients to compare the effect of doxapram versus theophylline on diaphragmatic function using ultrasonography parameter: thickening fraction of the diaphragmatic muscle during respiration which defined as [(thickness at end-inspiration - thickness at end-expiration)/thickness at end-expiration] during spontaneous breathing trial as a primary outcome and its effect on weaning time and weaning success rate as secondary outcomes. ;
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