The Effect of Doxapram Versus Theophylline on Diaphragmatic Function

Status Recruiting

Clinical Trial Summary

Doxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage.

Value of theophylline to stimulate the respiratory neuronal network has been examined by previous studies and increases the activity of respiratory muscles, including the intercostal , transversus abdominis muscles and the diaphragm, it also has bronchodilator and anti-inflammatory effects.

Clinical Trial Description

This randomized comparative study will be conducted in the post-surgical cardio-thoracic intensive care unit in Beni -Suef University Hospital after approval of the department of anesthesiology, surgical ICU and pain management , and cardio thoracic department and the local ethics and research committee, and obtaining written informed consents from the patients to compare the effect of doxapram versus theophylline on diaphragmatic function using ultrasonography parameter: thickening fraction of the diaphragmatic muscle during respiration which defined as [(thickness at end-inspiration - thickness at end-expiration)/thickness at end-expiration] during spontaneous breathing trial as a primary outcome and its effect on weaning time and weaning success rate as secondary outcomes. ;

Study Design

Related Conditions & MeSH terms

Weaning Failure

Clinical Trial Details

NCT number	NCT03894189
Study type	Interventional
Source	Beni-Suef University
Contact	Samaa ak Rashwan, MD
Phone	020120159125
Email	samakassemrashwan@gmail.com
Status	Recruiting
Phase	N/A
Start date	May 2019
Completion date	December 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05539599` - Comprehensive Ultrasound Evaluation as a Predictor of Weaning
Completed	`NCT02845076` - Weaning From Noninvasive Ventilation	N/A
Completed	`NCT01915563` - Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure	N/A
Recruiting	`NCT01721434` - Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients	Phase 2/Phase 3
Completed	`NCT01928277` - Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing	N/A
Recruiting	`NCT05632822` - Value of Diaphragm Function Predicting Weaning From Mechanical Ventilation
Completed	`NCT06332768` - NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients	N/A
Completed	`NCT03240263` - Inspiratory Muscle Training in Difficult to Wean Patients	N/A
Completed	`NCT01867853` - Volume Responsiveness Before SBT Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Patients	N/A
Recruiting	`NCT06040138` - Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure
Completed	`NCT06224010` - Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS
Completed	`NCT03129217` - The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
Completed	`NCT05550220` - A Modified Cuff Leak Test and Reintubation in Mechanically Ventilated Patients	N/A
Not yet recruiting	`NCT05431036` - Evaluation of a Combined Model in Predicting Weaning Outcome in Critically Ill Patients.
Recruiting	`NCT05906888` - Weaning With Tracheostomy - an Observational Study on Patient-centered Outcomes
Recruiting	`NCT05944588` - Predictive Value of Chest Ultrasound Observation on Extubation Failure
Not yet recruiting	`NCT05802745` - P0.1 and Extubation Failure in Critically Ill Patients
Completed	`NCT01877850` - Utility of a Weaning Protocol in ICU	N/A
Completed	`NCT03580720` - Electromyography for Diaphragm Effort	N/A
Recruiting	`NCT03880864` - Lung Ultrasound for Predicting Outcome of Weaning From Mechanical Ventilation	Phase 1