Mechanical Ventilation Complication Clinical Trial
Official title:
The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
This study is designed to determine whether maximal diaphragm thickening fraction measured by ultrasound during volitional maximal inspiratory efforts is a valid measure of diaphragm function in mechanically ventilated patients.
Classically, assessing diaphragm function requires direct measurements of transdaphragmatic
pressure generation. A critical requirement for valid measurements is a maximal volitional
patient effort. An alternative is to standardize the stimulus to the diaphragm using magnetic
twitch stimulation fo the phrenic nerve. This is the gold standard technique for diaphragm
function measurement in the respiratory physiology laboratory.
Twitch measurements require technical expertise and expensive equipment; this technique is
therefore basically limited to the laboratory. Bedside ultrasonography has been proposed as a
method for measuring diaphragm function by assessing the thickening of the muscle during a
maximal inspiratory effort. In order to achieve a maximal volitional effort in mechanically
ventilated patients, several methods may be employed: coached maximal efforts, coached
sniffing, and transient airway occlusion to stimulate respiratory drive (Marini maneuver).
The investigators are evaluating the validity of diaphragm functional assessment using
bedside ultrasound in combination with coached efforts/sniffing/Marini maneuver against the
gold standard technique: twitch transdiaphragmatic pressure.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05030337 -
Optimising Ventilation in Preterms With Closed-loop Oxygen Control
|
N/A | |
| Completed |
NCT05144607 -
Impact of Inspiratory Muscle Pressure Curves on the Ability of Professionals to Identify Patient-ventilator Asynchronies
|
N/A | |
| Recruiting |
NCT03697785 -
Weaning Algorithm for Mechanical VEntilation
|
N/A | |
| Completed |
NCT05084976 -
Parental Perception of COVID-19 Vaccine in Technology Dependent Patients
|
||
| Active, not recruiting |
NCT05886387 -
a Bayesian Analysis of Three Randomised Clinical Trials of Intraoperative Ventilation
|
||
| Completed |
NCT04429399 -
Lowering PEEP: Weaning From High PEEP Setting
|
N/A | |
| Completed |
NCT02249039 -
Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study
|
Phase 1 | |
| Recruiting |
NCT02071524 -
Evaluation of the Effects of Fluid Therapy on Respiratory Mechanics
|
N/A | |
| Completed |
NCT01114022 -
Prevention Inhalation of Bacterial by Using Endotracheal Tube Balloon Polyvinyl Chloride or Polyurethane
|
N/A | |
| Completed |
NCT00893763 -
Strategies To Prevent Pneumonia 2 (SToPP2)
|
Phase 2 | |
| Terminated |
NCT05056103 -
Automated Secretion Removal in ICU Patients
|
N/A | |
| Active, not recruiting |
NCT04558476 -
Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation
|
Phase 2 | |
| Recruiting |
NCT05295186 -
PAV Trial During SBT Trial
|
||
| Active, not recruiting |
NCT05370248 -
The Effect of 6 ml/kg vs 10 ml/kg Tidal Volume on Diaphragm Dysfunction in Critically Mechanically Ventilated Patient
|
N/A | |
| Completed |
NCT04589910 -
Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.
|
N/A | |
| Completed |
NCT04818164 -
Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
|
||
| Completed |
NCT04193254 -
LPP , MP and DP:Relation With Mortality and SOFA in Mechanically Ventilated Patients in ER, Ward and ICU
|
||
| Completed |
NCT06332768 -
NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
|
N/A | |
| Not yet recruiting |
NCT03245684 -
Assisted or Controlled Ventilation in Ards (Ascovent)
|
N/A | |
| Not yet recruiting |
NCT03259854 -
Non Invasive Mechanical Ventilation VERSUS Oxygen MASK
|
N/A |