Comparison of Cryotherapy and Peeling Agent in the Treatment of Common Warts

Warts Clinical Trial

Official title:

Cryotherapy Versus Topical Tricholoacetic Acid 90% in Treatment of Common Warts

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05712811
• Other study ID #: CMHAbbottabad
• Status: Completed
• Phase: N/A
• Start date: June 1, 2022
• Est. completion date: November 30, 2022

Study information

• Verified date: January 2023
• Source: Combined Military Hospital Abbottabad
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Objective: To compare the efficacy of cryotherapy using liquid nitrogen (cryoget method) versus trichloroacetic acid 90% (applicator method) in treatment of common warts.

Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from Jun 2022 to Nov, 2022.

Description:

A total of 60 patients were enrolled in this investigation by non-probability consecutive sampling technique. Sample size was calculated using WHO sample size calculator and patients were randomized into two equal groups, A and B, each comprising of 30 patients through lottery method. Patients with common warts such as hard lesions, raised lumps with rough surfaces at the back of their fingers, around nails and palm of their hands between the ages of 18 and 60 were included, whereas those with genital warts, cardiac, hepatic, renal, or hypercholesterolemia were excluded.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: November 30, 2022
• Est. primary completion date: November 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patient presented with common warts in dermatology opd

Exclusion Criteria:

• • Patients with warts on toes and tip of fingers

• genital warts

• cardiac, hepatic and renal disease

• hypercholesterolemia

• hypersensitivity reactions

Related Conditions & MeSH terms

• Warts

Intervention

Drug:
• CRYOTHERAPY
Group A had their warts treated once every two weeks for a total of twelve weeks, with liquid nitrogen using cryoget method for 10 to 15 seconds on each lesion (depending on size, until a narrow white rim of around 1 mm developed around it).
• Tricholoracetic acid
Group B were treated with liquid TCA 90% by an applicator every two weeks for a total of twelve weeks. After 20 minutes, patients were instructed to remove the solution by washing their warts with water or regular saline.

Locations

Country	Name	City	State
Pakistan	Cmh abbottabad	Abbottabad	Kpk

Sponsors (1)

Lead Sponsor	Collaborator
Combined Military Hospital Abbottabad

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison of cryotherapy and Tricholoracetic acid 90% in treatment of common warts	Outcome was determined at the end of third month and the patients were labelled as cured and the efficacy was labelled as "Yes" in cases with absence of all the lesions. After twelve weeks of therapy, individuals with persistent warts were regarded as cases of treatment failure and efficacy was labelled as "No".	12 weeks