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Does Steroid Plus CO2 Laser Improve Lichen Sclerosus Symptoms Compared to Steroids Alone?

Vulvar Lichen Sclerosus Clinical Trial

Official title:
A Randomized, Unblinded Trial of Topical Steroids Plus CO2 Laser Compared to Steroids Alone in the Treatment of Vulvovaginal Lichen Sclerosus

Clinical Trial Summary

This study will compare the effects of fractionated CO2 laser plus topical steroids versus topical steroids alone in treatment of lichen sclerosus.

Clinical Trial Description

Vulvar lichen sclerosus is a common benign skin condition which causes pain and itching. Topical steroids have been the main treatment. A recent study showed that fractionated CO2 laser treatment is non inferior and actually may improve subjective symptoms compared to topical steroids with no serious safety or adverse events. Because steroids reduce risk of vulvar cancer in patients with lichen sclerosus, the investigators hypothesize that steroids in addition to the fractionated laser will provide greater symptom relief while still allowing patient the benefits of steroid treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05243563
Study type Interventional
Source University of South Alabama
Contact Catera Duhon, RN, BSN
Phone 251-415-1598
Email cduhon@health.southalabama.edu
Status Recruiting
Phase Phase 2/Phase 3
Start date April 13, 2022
Completion date April 13, 2025
View Details
See also
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Completed NCT05251220 - Efficacy and Safety of the Neodymium Laser in Treatment of Urogenital Tract Diseases in Women
Completed NCT01400022 - Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus N/A
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Completed NCT00757874 - Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Phase 2