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Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease

Von Willebrand Diseases Clinical Trial

Official title:
A Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of VGA039 Following IV or SC Administration of Single Ascending Doses in Healthy Adults and Subcutaneous Adult Patients With Von Willebrand Disease

Clinical Trial Summary

This is a multi-center, Phase 1a study to assess the safety, tolerability, PK, and PD of VGA039 following single IV or SC dose administration in healthy subjects and Von Willebrand disease patients.

Clinical Trial Description

This first in human study consists of 2 parts based on the subject population: Part 1 and Part 2. Part 1 is a randomized, double-blind, placebo-controlled, single ascending dose (SAD) evaluation of IV or SC VGA039 or placebo in up to 8 cohorts. Part 2 is an open-label, SAD of SC and IV VGA039 in up to 8 cohorts. All participants will be enrolled, treated, and followed up for 15 weeks (IV SAD) or 8 weeks(SC SAD). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05776069
Study type Interventional
Source Vega Therapeutics, Inc
Contact Clinical Trials
Phone 650-466-8041
Email info@vega-therapeutics.com
Status Recruiting
Phase Phase 1
Start date March 16, 2023
Completion date December 2024
View Details
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