Von Hippel-Lindau Disease Clinical Trial
Official title:
Drivers of Hypoxia-induced Angiogenesis in Tumor Development
Verified date | September 2019 |
Source | University of Copenhagen |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The study aims to elucidate hypoxia-induced angiogenesis in tumor development using central
nervous system (CNS) hemangioblastoma tumorgenesis as a model.
In a pilot-project the investigators will identify genetic drivers of CNS hemangioblastoma
progression and associated cyst development using whole genome sequencing and copy number
profiling of tumor DNA paired with clinical information about each tumor's growth pattern.
The investigators will look for recurrent mutations across tumors to identify common genetic
mechanisms involved in early tumorigenesis.
Status | Enrolling by invitation |
Enrollment | 10 |
Est. completion date | May 31, 2020 |
Est. primary completion date | August 31, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Currently living, carrier of a pathogenic variant in the VHL gene, at least one surgically removed CNS hemangioblastoma that is accessible for the study. Exclusion Criteria: - Under the age of 18 years, deceased individuals |
Country | Name | City | State |
---|---|---|---|
Denmark | Department of Cellular and Molecular Medicine | Copenhagen | |
Denmark | Odense University hospital, department of clinical genetics | Odense |
Lead Sponsor | Collaborator |
---|---|
University of Copenhagen | Odense University Hospital |
Denmark,
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* Note: There are 18 references in all — Click here to view all references
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