Nausea Clinical Trial
Official title:
A Pilot Study on Efficacy and Safety of Olanzapine for the Treatment of Nausea and Vomiting in Palliative Cancer Care
Oral olanzapine showed superior antiemetic efficacy to metoclopramide as rescue treatment to control breakthrough emesis induced by chemotherapy. This study aims to evaluate safety and efficacy of olanzapine for nausea and vomiting in advanced cancer patients.
This will be a pilot study; open-label prospective clinical trial. Oral olanzapine 5 mg
tablet will be given to patients who fail two standard treatment medications for nausea and
vomiting within 30 minutes after the first vomiting episode. Other doses of olanzapine will
be given at 12, 24, and 36 hours following the first dose concurrently with standard regimen.
Patients with emesis will be followed up after receiving olanzapine every 12 hour for 48
hours. We will record the frequency of vomiting, nausea, and retching.
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