Inflammatory Bowel Disease Clinical Trial
Official title:
Analysis of Volatile Organic Compounds in Exhaled Air in Patients With Inflammatory Bowel Disease Patients and Healthy Control
The availability of noninvasive biomarkers for diagnosis and stratification of inflammatory bowel disease (IBD) courses is lacking. Thus, the aim of this study is to evaluated the accuracy of exhaled breath volatile metabolite analysis on diagnosis and stratification of patients with inflammatory bowel disease.
Background: The diagnosis and differentiation of inflammatory bowel diseases (IBD) is
challenging due to the absence of a gold standard diagnostic modality for confirmation.
Exhaled breath volatile metabolite analysis focusing on diagnosis and differentiation of IBD
is a promising approach. Thus, the aim of this study is to evaluated the accuracy of exhaled
breath volatile metabolite analysis for patients with inflammatory bowel disease.
Method: A single center, prospective study of diagnostic testing will be conducted,
recruiting crohn's disease (CD), ulcerative colitis (UC), and healthy controls (HC). The
exhaled breath volatile metabolite will be analyzed using gas chromatography/mass
spectrometry (GC-MS). The informations of patient's disease location, disease activity,
laboratory parameters and current medications will be collected to determine the feasibility
of exhaled breath volatile metabolite analysis.
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