Clinical Implication of DAC (Detrusor After-contraction)

Voiding Dysfunction Clinical Trial

— DAC  

Official title:

A New Approach to Clinical Implication of Detrusor After-contraction (DAC)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01154946
• Other study ID #: DAC
• Secondary ID: H-0805-056-245
• Status: Completed
• Phase: N/A
• First received: June 29, 2010
• Last updated: June 30, 2010
• Start date: January 2007
• Est. completion date: December 2008

Study information

• Verified date: June 2010
• Source: Seoul National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The aims of this study are

• to confirm whether detrusor after-contraction (DAC) is a true contraction or not with a new approach

• and to understand clinical implication of DAC

Description:

The definition of detrusor after-contraction (DAC) is usually accepted as the increase of detrusor pressure (Pdet), whether it is sudden or not, after cessation of urinary flow. The amount of increase in Pdet is sometimes included in the definition of DAC (14, 15, 20 cmH2O or at least two times the level of the maximal Pdet during the voiding phase). However, it is clear that the lack of a well-established definition may induce much bias in the interpretation of the clinical implication of DAC. The previous studies showed a wide range of prevalence.1-4 DAC seemed to occur more frequently in children and the occurrence rate usually decreased with age in urodynamic studies.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2309
• Est. completion date: December 2008
• Est. primary completion date: December 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Indications and selection of patients for conduction of urodynamic studies (UDS) were followed as the recommendation of ICS (international continence society).

Exclusion Criteria:

• Patients with indwelling catheters, urinary tract infection and urinary stones were excluded from this study

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Voiding Dysfunction

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (1)

Ruarte AC, Podestá ML, Medel R. Detrusor after-contractions in children with normal urinary tracts. BJU Int. 2002 Aug;90(3):286-93. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	to confirm whether DAC is a true contraction or not	no change of Pdet when patients cough could confirm that DAC was a true contraction. Because an artifact occurred when a catheter was pressed against bladder wall or urethra, no change of intravesical pressure and increase of abdominal pressure finally induced a negative deflection of Pdet and this change of Pdet could be regarded as an artifact.	up to 2 years (2007.Jan-2008.Dec)	No
Secondary	Past medical history including neurological disorders and pelvic irradiation were also included in the database	One-way analysis of variance and the chi-square test were performed to determine whether there was a relationship between the presence of DAC and the underlying neurogenic and non-neurogenic conditions	up to 2 years (2007.Jan-2008.Dec)	No