Voice Disorder Clinical Trial
Official title:
Sensory Function in Idiopathic Voice Disorders
This research study is designed to improve understanding about voice disorders that are due
to uncontrolled muscle contractions affecting the voice box. The type of voice disorder
depends on which muscles of the voice box are involved. Abductor spasmodic dysphonia may lead
to a weak voice. Adductor spasmodic dysphonia may result in a strangled voice. Muscular
tension dysphonia may lead to a strained voice. Some of the major goals of the study are to;
1. understand how sensation from the voice box affects voice and speech production
2. develop better ways to diagnose sensation abnormalities affecting the voice box
3. determine if patients with voice disorders differ from persons without voice disorders
in the way they respond to sensory information from their voice box
Researchers believe that by understanding better how sensations of the voice box are
presented and how the muscles in the larynx respond to those sensations they will be able to
develop better treatments for patients suffering from voice disorders. ...
Study Aim One: To develop and validate objective procedures for quantifying efferent
responses to non-invasive laryngeal mechanical and aerodynamic stimulation.
Study Aim Two: To develop and validate an objective test of brain stem evoked responses to
laryngeal stimulation using electrical stimulation of the superior laryngeal nerve.
Study Aim Three: To determine whether individuals with idiopathic voice disorders have
abnormal conditioning of their responses to laryngeal mechanical and aerodynamic stimulation.
Study Aim Four: To determine whether individuals with idiopathic voice disorders have
abnormal brain stem responses to laryngeal stimuli.
Study Aim Five: To evaluate whether sensory input plays a role in symptom generation in
laryngeal motor control disorders, temporary bilateral ISLN blockade will be used in
idiopathic voice disorders.
Study Aim Six: To evaluate whether the central pathophysiology involved in motor responses to
sensory stimulation are altered by botulinum toxin injection in individuals with spasmodic
dysphonia.
Study Aim Seven: To evaluate central responses to laryngeal afferent stimulation in normal
volunteers and patients with idiopathic voice disorders at rest and during vocalization using
magnetoencephalography.
These studies will develop improved non-invasive techniques for the diagnosis of laryngeal
sensory disorders and will determine if abnormalities in sensory feedback modulation are
involved in idiopathic voice disorders. Such findings will lead to improved understanding of
the pathophysiology and differential diagnosis of idiopathic voice disorders and may
ultimately improve treatment approaches to these disorders.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03696576 -
Expiratory Muscle Strength Training and Phonation Resistance Training Exercises For Elderly Patients With Vocal Fold Atrophy
|
N/A | |
| Completed |
NCT01199172 -
Prevention and Treatment of Voice Problems in Teachers
|
N/A | |
| Completed |
NCT00001552 -
Characteristics of Idiopathic Familial Voice Disorders
|
N/A | |
| Terminated |
NCT00001308 -
Central Mechanisms in Speech Motor Control Studied With H215O PET
|