The Mechanism of Melanocyte Self-Assembly on Biomaterials and the Functional Analysis

Vitiligo Clinical Trial

Official title:

The Mechanism of Melanocyte Self-Assembly on Biomaterials and the Functional Analysis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00509314
• Other study ID #: 9561703036
• Status: Recruiting
• Phase: N/A
• First received: July 29, 2007
• Last updated: July 29, 2007
• Start date: May 2006
• Est. completion date: December 2016

Study information

• Verified date: May 2006
• Source: National Taiwan University Hospital
• Contact: Sung-Jan Lin, MD PhD
• Phone: +886-2-23123456
• Email: jsjl2000tw[@]yahoo.com.tw
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

The aim of this study is to survey melanocytes in the ability of self-assembly on biomaterials and functional analysis in vitro. Also, this study may provide a better way for treatment of vitiligo after understanding the functional aspects of melanocytes.

Description:

Vitiligo is a chronic disease that causes loss of melanocyte and pigment of the skin. Traditional treatments for vitiligo including topical corticosteroids and phototherapy lead to limited clinical effects. Autologous melanocyte transplantation is another way to treat vitiligo. However, the effect is largely affected by whether cultivated melanocytes are successfully uptaken by vitiliginous skin. The aim of this study is to survey the self-assembly on biomaterials and functional analysis. In the long run, this study may provide a better way for treatment of vitiligo.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 400
• Est. completion date: December 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patients receiving cosmetic removal of moles

Exclusion Criteria:

• No special exclusion criteria

Study Design

Observational Model: Natural History, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Melanocyte
• Vitiligo

Intervention

Behavioral:
• melanocyte self-assembly and functional analysis

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (3)

Lead Sponsor	Collaborator
National Taiwan University Hospital	National Health Research Institutes, Taiwan, National Science Council, Taiwan

Country where clinical trial is conducted

Taiwan, 

References & Publications (2)

Lin SJ, Jee SH, Hsaio WC, Lee SJ, Young TH. Formation of melanocyte spheroids on the chitosan-coated surface. Biomaterials. 2005 Apr;26(12):1413-22. — View Citation

Lin SJ, Jee SH, Hsiao WC, Yu HS, Tsai TF, Chen JS, Hsu CJ, Young TH. Enhanced cell survival of melanocyte spheroids in serum starvation condition. Biomaterials. 2006 Mar;27(8):1462-9. Epub 2005 Sep 19. — View Citation