Clinical Trials Logo

Clinical Trial Summary

Vitamin D deficiency is considered a public health priority in the UK, with approximately 30-40% of the UK population being deemed vitamin D deficient during winter months. Current government strategies to improve vitamin D status amongst the UK population involve dietary supplementation, however, it has been shown that excess adiposity reduces the impact of dietary supplementation with vitamin D. One potential explanation for this observation is that vitamin D becomes sequestered in adipose tissue. We hypothesise that exercise may facilitate the mobilisation of vitamin D from adipose tissue and thus increase circulating vitamin D (25OHD) concentrations. Little is currently known as to whether a single bout of exercise affects vitamin D status, with a handful of studies demonstrating contradictory findings. This research will examine the effect of an acute bout of exercise (treadmill-based at 60% VO2 Max for 60 minutes) on vitamin D status (serum 25(OH)D) in healthy community-dwelling adults.

Clinical Trial Description

This study is a random crossover design and will require 34 participants to visit the University of Bath on 6 separate occasions in total. Individuals who express an interest in taking part will be invited to attend an initial screening meeting at the University so that the eligibility can be assessed for the study, and the all procedures explained verbally. If the participant is eligible and is happy to participate in the study, they will attend a second visit prior to two trials to undertake a treadmill-based maximal exercise test (VO2 Max), resting metabolic rate measure and several measures will be taken to assess body composition. Trials will involve a 60-minute exercise bout at 60% of the participant's maximum oxygen uptake or a 60-minute resting period (both followed by a further hour of rest). The order in which these trials occur will be randomised for each participant and the participant will not be told of this order prior to the trials. During both trials, a cannula will be inserted into a vein in the arm prior to exercise and 10ml blood samples will be drawn at baseline (pre-exercise) and immediately after the exercise session and 1 hour post exercise from the antecubital vein. The participant will return to the university the day after each trial for a 10ml venous blood sample (24hr post-exercise) which will be taken via venepuncture. In the 24 hours following a trial, participants will be provided with standardised meals in order to ensure energy balance. Other controls which will be applied during the study period will include the provision of factor 50 sunscreen (if the participant is undertaking trials between March and October) to aid in mitigating against the cutaneous synthesis of vitamin D, and guidance on avoiding any strenuous activity 24 hours prior to trial days. Participants will also be provided with a physical activity monitor (MotionWatch8, CamNTech) to wear during trial days after leaving the lab. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05214027
Study type Observational
Source University of Bath
Status Completed
Start date April 1, 2021
Completion date November 1, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT05186194 - The Effect of Vitamin D and Calcium Supplementation on the Prevention of Stress Fractures. N/A
Recruiting NCT06101147 - Effect of Vitamin D Supplementation on Testosterone Level in Women With Polycystic Ovary Syndrome Phase 2
Completed NCT02904421 - 6 Years Study on Changes in Bone Quality, Bone Turnover and Curve Severity in AIS With and Without Calcium and Vit-D Supplementation
Completed NCT02092701 - Effects of Cholecalciferol Supplementation on Bone Health and Muscle Strength in Adults During Post-burn Period N/A
Completed NCT05748249 - Evaluation of the Efficacy of Vertistop® D and Vertistop® L in the Prevention of BPPV Recurrence Phase 1
Recruiting NCT04844957 - Correlation Between Vitamin D and Symptoms Severity of Autonomic Nervous Mediated Syncope Child and it 's RAAS Early Phase 1
Completed NCT05313477 - The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF Phase 4
Completed NCT01170572 - Longitudinal Study of Patients Following Long Bone Fracture N/A
Not yet recruiting NCT01080950 - Vitamin D Zinc Fever N/A
Active, not recruiting NCT04564625 - Relationships Between Vitamin D and Orthopedic Trauma
Not yet recruiting NCT01992263 - Vitamin D Supplementation and TB N/A
Completed NCT00938600 - Antenatal Vitamin D3 Dose-finding and Safety Study Phase 1
Completed NCT04502667 - Efficacy of Vitamin D Treatment in Pediatric Patients Hospitalized by COVID-19 Phase 3
Completed NCT04535791 - Efficacy of Vitamin D Supplementation to Prevent the Risk of Acquiring COVID-19 in Healthcare Workers Phase 3
Recruiting NCT05448365 - Vitamin D, Epigallocatechin Gallate, D-chiro-inositol and Vitamin B6 in Uterine Fibroid Phase 3
Recruiting NCT03533010 - Preventing Curve Progression and the Need for Bracing in Adolescent Idiopathic Scoliosis With Calcium + Vitamin D Supplementation N/A
Recruiting NCT04404842 - Development of a Screening Tool for the Risk of Vitamin D Deficiency
Recruiting NCT05208827 - Vitamin D Supplementation for the Prevention of GDM Early Phase 1
Completed NCT05209425 - Pharmacokinetics Evaluation of Vitamin D Formulations N/A
Withdrawn NCT03073369 - Effect of Ergocalciferol on Iron Metabolism in Individuals With Chronic Kidney Disease Phase 4