Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-eclampsia

Status Completed

Clinical Trial Summary

Vitamin D deficient pregnant ladies were selected and randomized into 2 groups for routine daily dose of multivitamin (400IU vitamin D3) versus maximum safest treatment daily dose (4000IU vitamin D3). Participants were assessed and compared for number of pre-eclampsia cases.

Clinical Trial Description

Vitamin D3 has key role in decidualization and implantation of placenta.Vitamin D deficiency is thought to have positive association with pre-eclampsia.Vitamin D deficiency is highly prevalent in some parts of the world and it is not universally screened antenatally. Pre-eclampsia is a known multifactorial pregnancy disorder with significant maternal and perinatal morbidity and mortality. Vitamin D3 has a down-regulating effect on inflammatory pathways and reducing endothelial cell damage.

Investigators want to assess in vitamin D deficient group whether treatment reduces the risk of pre-eclampsia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03101150
Study type	Interventional
Source	King Fahad Medical City
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	October 1, 2012
Completion date	December 31, 2015

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