Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

Vitamin D Deficiency Clinical Trial

Official title:

A Pilot Study Investigating Differences in Muscle Metabolic Function in Individuals Aged 65-75 Years With Different Vitamin D Status Before and After 7-days of Aerobic Training

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02485197
• Other study ID #: 12-1029-F6A
• Status: Completed
• Phase: N/A
• First received: April 25, 2013
• Last updated: March 15, 2017
• Start date: March 2013
• Est. completion date: June 2015

Study information

• Verified date: March 2017
• Source: University of Kentucky
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 7
• Est. completion date: June 2015
• Est. primary completion date: October 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 75 Years

Eligibility

Inclusion Criteria:

• 65-75 years of age

Exclusion Criteria:

• Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise.

• Uncontrolled diabetes or hypertension.

• History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity

• History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months

• Have a diagnosis of osteoporosis (as determined by DXA)

• Participated in a resistance or aerobic training program in the last 3 months

• Engage in more than 1 hr/week of vigorous activity

• Body mass index >29

• On hormone replacement therapy

Related Conditions & MeSH terms

• Vitamin D Deficiency

Intervention

Other:
• 7 continuous days of aerobic training
For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.

Locations

Country	Name	City	State
United States	University of Kentucky	Lexington	Kentucky

Sponsors (1)

Lead Sponsor	Collaborator
David Travis Thomas

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle VO2 consumption	The objective is to examine the difference in gastrocnemius VO2 consumption in individuals that either have normal-high or low 25(OH)D and are undergoing 7-days of a treadmill training program.	Up to 3 months