Vitamin B12 Deficiency Clinical Trial
Official title:
Holotranscobalamin Remains Unchanged During Pregnancy. Longitudinal Changes of Cobalamins and Its Binding Proteins During Pregnancy and Postpartum
Verified date | April 2007 |
Source | University of Aarhus |
Contact | n/a |
Is FDA regulated | No |
Health authority | Denmark: Ethics Committee |
Study type | Observational |
Background and objective: Plasma cobalamins decrease during pregnancy but it is not fully
elucidated how this is reflected in the total and cobalamin saturated transport proteins,
transcobalamin (total TC, holoTC) and haptocorrin (total HC, holoHC). TC transports
cobalamin into the cells. The function of HC is unknown, but in contrast to TC it binds both
cobalamins and cobalamin analogues.
Design and methods: Healthy pregnant women (N=141) had blood samples drawn at 18th, 32nd,
39th gestation week and 8 weeks postpartum. The protein moiety of TC and HC (total and holo)
was measured by in-house ELISA methods.
Status | Completed |
Enrollment | 150 |
Est. completion date | December 1997 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - Danish healthy Caucasian women >18 years of age with previous uncomplicated pregnancies and deliveries and presently with a normal pregnancy. Exclusion Criteria: - >4 cigarettes smoked per day, - Treatment with vitamin B12, folic acid or acetyl salicylic acid, - Impaired renal function and clinically significant vaginal haemorrhage before first visit as well as blood haemoglobin <6.4 mmol/L at first visit. |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Denmark | Nils Milman | Copenhagen |
Lead Sponsor | Collaborator |
---|---|
University of Aarhus | University of Copenhagen |
Denmark,
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