Vitamin A Deficiency Clinical Trial
Official title:
Effects of Environmental Enteric Dysfunction (EED) on Zinc (Zn) Absorption and Retention in Young Children: Study 1 - Absorption of Zn and Vitamin A From a Standard Dose
The overall objective is to determine the impact of EED on zinc absorption and homeostasis, and its impact on the absorptive capacity of vitamin A absorption of young children (18-24 months of age) in an austere setting with high rates of diarrhea, stunting, and micro-nutrient deficiencies.
Participating children are screened for EED using the lactulose:mannitol ratio test and
assigned to one of two groups: +EED or -EED. All participants will be given standard,
physiological dose of 3 mg zinc sulfate with a zinc stable isotope tracer on study day 8.
On study day 11, 0.5 mg of 13C10-retinyl-acetate will be administered orally to all
participants.
Spot urine samples will be collected twice daily from study days 11-14. Complete fecal
collections will be obtained for days 11-14. Duplicate diets of all foods consumed will be
collected on days 11-14. On study day 14, a blood sample will be taken for analysis of
vitamin A isotope status.
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