Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment

Vitamin A Deficiency Clinical Trial

Official title:

Estimating Dietary Vitamin A Requirement in Chinese Children by Stable-isotope Dilution Technique

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01559766
• Other study ID #: No.2008BAI58B03
• Status: Completed
• Phase: N/A
• First received: March 19, 2012
• Last updated: March 20, 2012
• Start date: July 2009
• Est. completion date: September 2010

Study information

• Verified date: March 2012
• Source: Huazhong University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Ministry of Science and Technology
• Study type: Observational

Clinical Trial Summary

Vitamin A deficiency remains a major public health problem in developing country worldwide. Young Children are considered to be at greatest risk of deficiency. However, there is little information on the vitamin A requirement of Chinese children. In the present study, about 400 children aged between 4 and 9 years old in a kindergarten and an elementary school of Shiyan City were screened before admission by questionnaire and anthropometric measurement. The vitamin A status of children was assessed by serum vitamin A level, relative dosage reaction and stable-isotope dilution technique. At the same time, their dietary vitamin A intakes were estimated by weighted-food dietary survey. The dietary vitamin A requirement in young children was determined on the basis of dietary vitamin A intakes in Children with adequate vitamin A level.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 403
• Est. completion date: September 2010
• Est. primary completion date: July 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 4 Years to 9 Years

Eligibility

Inclusion Criteria:

• well-nourished children with normal serum retinol(>=1.40umol/L)

Exclusion Criteria:

• ongoing or previous illnesses,

• having taken nutritional supplements within 3 months,

• positive results in the fat absorption test or parasite test,

• increased level of CRP (> 8 mg/L), or

• lower serum level of retinol (< 1.40 umol/L)

Study Design

Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Night Blindness
• Vitamin A Deficiency

Locations

Country	Name	City	State
China	Shiyan Centre for Disease Control and Prevention	Shiyan	Hubei

Sponsors (3)

Lead Sponsor	Collaborator
Huazhong University of Science and Technology	ShiYan Centre for Disease Control and Prevention, Tufts Medical Center

Country where clinical trial is conducted

China,