Vitamin A Deficiency Clinical Trial
— ObaapaVitAOfficial title:
Randomised Double-blind Placebo-controlled Trial to Evaluate the Impact of Vitamin A on Maternal Mortality in Ghana
Verified date | February 2010 |
Source | London School of Hygiene and Tropical Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Main objectives: To evaluate the impact of weekly vitamin A supplementation (VAS) to women of
reproductive age (15-45 years) on maternal mortality in rural Ghana, and to compare this with
the impact on overall mortality.
Hypotheses:
1. Weekly supplementation with vitamin A (7000 µg retinol equivalent [RE]) to reproductive
age women will reduce maternal deaths by 33%.
2. This impact will be achieved by reductions in both pregnancy-related and
non-pregnancy-related deaths.
3. There will be a reduction in non-maternal deaths, similar in size to that in maternal
non-pregnancy related deaths.
Outcome measures: Maternal mortality rate, and overall mortality rate. Deaths will be
identified through monthly demographic surveillance, and classified as maternal
(pregnancy-related, non-pregnancy-related) or non-maternal using verbal autopsies.
Status | Completed |
Enrollment | 100000 |
Est. completion date | October 2008 |
Est. primary completion date | October 2008 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 15 Years to 45 Years |
Eligibility |
Inclusion Criteria: - All women of reproductive age (15 to 45 years) who are permanent residents in any of the 4 districts in rural Ghana (Kintampo, Wenchi, Techiman, and Nkoranza) Exclusion Criteria: - There will be no exclusions to participation, except for women who are unable to give their informed consent to join the study |
Country | Name | City | State |
---|---|---|---|
Ghana | Kintampo Health Research Centre | Kintampo | Brong Ahafo |
Lead Sponsor | Collaborator |
---|---|
London School of Hygiene and Tropical Medicine | Kintampo Health Research Centre, Ghana |
Ghana,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pregnancy-related mortality and all cause mortality | Continuous | ||
Secondary | Severe maternal morbidity (based on Hospital admissions) | Continuous | ||
Secondary | perinatal mortality | Continuous | ||
Secondary | Infant mortality | Continuous |
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