Vitamin A Deficiency Clinical Trial
To determine vitamin A value of beta-carotene in oil capsule, spinach, and golden rice.
The experiments will be conducted in children (ages 7-9) with/without adequate vitamin A
nutrition. As plant provitamin A carotenoids are a major and safe vitamin A source for a
vast population in the world, it is essential to determine the efficiency of provitamin A
carotenoid (mainly ß-C) conversion to vitamin A. By introducing ß-C into rice endosperm,
Golden Rice may directly benefit consumers by providing vitamin A nutrition. Our
investigation uses hydroponically grown, deca-deuterium labeled spinach and Golden Rice,
synthetic ß-C-d10 and a vitamin A isotope reference, deca-deuterated retinyl acetate
(RAc-d10), to evaluate the bioavailability and the bioconversion of plant provitamin A
carotenes to retinol as compared with ß-C in oil capsules in vivo.
Our objectives will be to test the following hypotheses and to make the following
determinations: (1) The absorption and bio-conversion of provitamin A carotenes taken by
children are different between spinach, Golden Rice, and ß-C in oil capsules. (2) The
absorption of provitamin A carotenes and their bioconversion to vitamin A are different in
children with or without adequate vitamin A nutrition. (3) To define the vitamin A
equivalence(s) of dietary spinach, Golden Rice, and a ß-C in oil dose by using an isotope
reference method in children with or without adequate vitamin A nutrition and to compare
those values with values derived from model based compartmental analysis. (4) To determine
the number and time of blood samples needed for future studies in various field settings on
the retinol equivalence of a large number of plant sources.
This study will be of importance in planning vitamin A deficiency prevention strategies and
also will provide useful information regarding the potential efficacy of a bioengineered
crop to provide vitamin A nutrition.
Status | Completed |
Enrollment | 32 |
Est. completion date | November 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 7 Years to 9 Years |
Eligibility |
Inclusion Criteria: - 7-9 years old Exclusion Criteria: - Parasitic infection |
Observational Model: Case-Only
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Lei Li, Yin Wang, Jieshu Wu, Ranfeng Zhu, Xianfeng Zhao, Zhixu Wang, Shi-an Yin. Biefficacy of ß-carotene in Chinese children with marginal and normal vitamin A status (in Chinese). Hygiene Research, 2007;36(5):547-551.
Lei Li, Yin Wang, Shi-an Yin, Michael A Grusak, Robert M Russell, Guangwen Tang. Bioconversion of spinach ß-carotene in Chinese children with noemal or marginal vitamin A status. FASEB J. 2006 20:A1319
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