Clinical Trials Logo

Clinical Trial Summary

During visual fixation, small eye movements of which we are usually not aware, prevent the maintenance of a steady direction of gaze. These eye movements are finely controlled and shift retinal projection of objects within the fovea, the region of the retina where visual acuity is highest. This program of research examines the link between these eye movements and attention, and tests the hypothesis that attention, similarly to eye movements, can be controlled at the foveal level. Psychophysical experiments with human subjects, using state-of-the-art techniques, high resolution eyetracking and retinal stabilization are conducted to address these questions. Gaze-contingent calibration procedures are employed to achieve high accuracy in gaze localization. A custom developed gaze-contingent display is used to shift in real-time visual stimuli on the monitor to compensate for the observer eye movements during fixation periods and to maintain stimuli at a desired location on the retina. Experiments involve visual discrimination/detection tasks with stimuli presented at selected eccentricities within the fovea. Participants' performance and reaction times are examined under different conditions, in which various types of attention are manipulated. In addition to advancing our basic understanding of visual perception, this research leads to a better understanding of attentional control at the foveal scale and of the contribution of microscopic eye movements to the acquisition and processing of visual details.


Clinical Trial Description

The goals of this study are to the following: 1. Examine the resolution and time-course of attention within the foveola. Attentional control has been traditionally studied outside the foveola but the PI's recent work suggests that attentional shifts also play a critical role in the normal examination of fine spatial details. Building on our previous results, we will investigate the extent by which both voluntary and involuntary attention can be controlled at this scale. Specifically, we will (a) measure the resolution of attention, i.e., the minimum distance between two locations within the foveola that can elicit selective voluntary attentional shifts. We will (b) examine whether enhancements in fine spatial vision at selected foveal locations, such as those we have previously shown for voluntary attention, also occur with involuntary attention. Finally we will study (c) the time-course of attentional enhancements and inhibition of return at this scale. Moreover, to study how peripheral and foveal attention differ, we will compare the extent of exogenous attentional effects and their time-course within and outside the foveola. 2. Map visual acuity and crowding across the foveola. Our research has shown that vision is not uniform across the foveola: discrimination of fine spatial patterns is already suboptimal just a few arcmins away from the center of gaze. This phenomenon could be caused by a decline in visual acuity outside the preferred retinal locus and/or the consequences of crowding, the negative influence resulting from objects adjacent to the target. Because of the difficulty in precisely controlling retinal stimulation at this scale, it is unclear whether crowding occurs in the foveola, and whether its influence changes with foveal eccentricity. We will measure both visual acuity (a), and crowding (b), and will assess their relative contribution over a range of foveal eccentricities, both nasally and temporally. In addition to examine visual acuity across subjects, we will also examine how it changes at the individual level. 3. Link attention, fine spatial vision and oculomotor control. Microsaccades normally shift the retinal projection of the fixated object across the foveola. At a larger scale, visual resolution, attention, and eye movements are tightly coupled. But little is known on whether and how this interplay unfolds within the foveola. Here we will investigate how attention and vision interact with microsaccades preparation and execution. We will examine (a) whether microsaccades preparation yields attentional benefits at specific foveal locations; (b) the precision of microsaccades; (c) their impact in attenuating negative effects of reduced acuity and foveal crowding, and; (d) their impact on performance in natural high acuity tasks. To address these goals psychophysics experimental paradigms and high-precision eyetracking will be used. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03884985
Study type Interventional
Source University of Rochester
Contact Martina Poletti, Ph.D.
Phone 6175953785
Email martina.poletti@gmail.com
Status Recruiting
Phase N/A
Start date January 1, 2018
Completion date February 1, 2024

See also
  Status Clinical Trial Phase
Recruiting NCT05419713 - Intermediate Visual Space Perception N/A
Completed NCT00713076 - Wettability of Contact Lenses With a Multi-Purpose Solution N/A
Completed NCT04065061 - Erinacine A-enriched Hericium Erinaceus Mycelia for Improvement of Recognition, Vision, and Functional MRI Alterations N/A
Withdrawn NCT00886249 - Depth of Focus Comparison Between Acrysof IQ and Acrysof Natural IOLs
Completed NCT00591110 - Project inCharge: Increasing the Rate of Comprehensive Eye Care Utilization by Older African Americans Through Community-Based Eye Health Education Program N/A
Completed NCT02033200 - Safety Study Looking at the Effects of Stendra on Vision Phase 4
Withdrawn NCT01062672 - Functional Neuroimaging of Cortical Plasticity in the Human Visual System
Completed NCT01057966 - Bioavailability of Nutrients Contained in Softgel Capsules vs Tablets Phase 4
Completed NCT01138228 - Does the VTS1000 Infra Red Vein Imager Allow Better Identification of Veins Than Normal Eyesight? N/A
Recruiting NCT00768586 - Analysis of the Early Development of the Visual Function in Extreme Premature Infants Under 28th Weeks of Gestation N/A
Completed NCT00357409 - GABA Levels in the Brains of Blind People N/A
Completed NCT05533658 - The Effects of VisionPureâ„¢ on Indices of Vision Health and Cognitive Function N/A
Recruiting NCT04332783 - Isolating and Mitigating Sequentially Dependent Perceptual Errors in Clinical Visual Search N/A