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Virus Shedding clinical trials

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NCT ID: NCT05794412 Active, not recruiting - Clinical trials for SARS-CoV-2 Infection

Mucosal Immunity: Influence on Infectious Viral Load: a Prospective Observational Study

MIViral
Start date: January 10, 2023
Phase:
Study type: Observational

The goal of this observational study is to learn about the influence of pre-existing mucosal immunity, i.e. antibodies and immune cells that are present at the nasal mucosa before infection, on the infectious viral load after infection with SARS-CoV-2, influenza virus and RSV. The investigators will include app. 320 participants which will be followed for up to 17 months. During this time, the investigators will monitor their nasal mucosal antibodies at regular intervals and compare them to their infectious viral load if they are infected with SARS-CoV-2, influenza virus or RSV. Participants are invited to take a test for SARS-CoV-2, influenza virus or RSV in case of respiratory symptoms. If participants are positive the investigators will follow their viral load kinetics by taking nasopharyngeal swabs every 2-3 days. The investigators will also record the duration and strength of the following symptoms: - Cough - Fever - Tired - Sore throat - Difficulty breathing - Respiratory distress - Headache - Loss (or alteration) of smell - Loss (or alteration) of sense of taste - Myalgias - Chills - Subjective fever - Pink sputum (or coughing up blood) - Thoracic pain - Runny nose - Abdominal pain - Nausea - Vomiting - Diarrhea - Constipation - Irritated or watery eyes - Rashes - Other

NCT ID: NCT04382131 Recruiting - COVID Clinical Trials

Hypertonic Saline Nasal Irrigation and Gargling in Suspected or Confirmed COVID-19 (ELVIS COVID-19)

Start date: June 23, 2020
Phase: N/A
Study type: Interventional

ELVIS COVID-19 is a pragmatic web-based Bayesian adaptive randomised controlled, parallel group trial of hypertonic saline nasal irrigation and gargling (HSNIG) compared to standard care in participants with clinically suspected or confirmed COVID-19 being managed at home.

NCT ID: NCT03463694 Completed - Pediatric ALL Clinical Trials

Edinburgh and Lothian Virus Intervention Study in Kids

ELVIS Kids
Start date: November 2, 2018
Phase: N/A
Study type: Interventional

ELVIS Kids is a parallel, open label, randomised controlled trial (RCT) of Hypertonic Saline (HS) nose drops (~2.6% NaCl) vs. standard care in children <7 years of age with symptoms of an Upper Respiratory Tract Infection (URTI).

NCT ID: NCT02733796 Completed - Zika Virus Clinical Trials

Persistence of Zika Virus in Semen After Acute Infection

Start date: February 1, 2016
Phase:
Study type: Observational

This is a prospective observational laboratory evaluation of the persistence rate of zika virus (ZIKV) infection in semen by real-time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR), and assessment of ZIKV replication-competence in semen by isolation of ZIKV. Evaluation of the persistence of ZIKV and its replication-competence in semen samples will increase the understanding of the risk of sexual transmission of ZIKV infection in the post-viremic phase in non-epidemic settings.

NCT ID: NCT02638493 Active, not recruiting - Clinical trials for Human Immunodeficiency Virus

The Compartmental Biology of HIV in the Male Genital Tract

Start date: November 2015
Phase: N/A
Study type: Observational

Male participants taking tenofovir-emtrictabine (TDF/FTC) will provide semen and blood samples which will be analyzed to better understand the pharmacology of antiretroviral therapy in the male genital tract.