Virus Diseases Clinical Trial
Official title:
Avian Influenza Studies In Lebanon
The highly pathogenic avian influenza (HPAI) H5N1 virus arrived in the Middle East in 2005
and has since established itself in local domestic birds and is now considered endemic in
several Middle Eastern countries.Few studies indicate the presence of low pathogenicity
avian influenza (LPAI) viruses of the H9 type among Lebanese poultry and wild birds. These
studies also provide some evidence suggesting that humans exposed to these sick birds are
showing elevated antibody titers against these LPAI H9 viruses.
This study will focus on the following objectives:
- To determine the seroprevalence of AI in poultry-exposed and non-exposed human
populations.
- To identify risk factors associated with AI infections in occupationally-exposed
poultry workers.
- To conduct nation-wide cross-sectional surveillance for AI viruses among domestic birds
in low biosecurity farms and backyard flocks.
Status | Completed |
Enrollment | 250 |
Est. completion date | December 2010 |
Est. primary completion date | December 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Be at least 18 years old. - Be willing to participate by signing a consent form, completing the study questionnaire, and providing a blood sample. Exclusion Criteria: - Less than 18 years old. - Any known immunosuppressive condition or immune deficiency disease (including HIV infection), or ongoing receipt of any immunosuppressive therapy. (Note that we have chosen to exclude such populations because of their increased risk of acquiring infections, they are relatively few, and are not representative of a national sample). - Any individual with unknown poultry exposure status, or who was exposed to poultry more than 5 years ago. |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
Lebanon | American University of Beirut | Beirut | |
United States | St. Jude Children's Research Hospital | Memphis | Tennessee |
Lead Sponsor | Collaborator |
---|---|
St. Jude Children's Research Hospital | American University of Beirut Medical Center |
United States, Lebanon,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The seroprevalence of Avian Influenza in poultry-exposed and non-exposed human populations. | 1 year | No | |
Primary | Risk factors associated with AI infections in occupationally-exposed poultry workers. | 1 year | No | |
Primary | Nation-wide cross-sectional surveillance for AI viruses among domestic birds in low biosecurity farms and backyard flocks. | 1 year | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04074928 -
Safety and Immunogenicity Study of QIVc in Healthy Pediatric Subjects
|
Phase 3 | |
Completed |
NCT03321968 -
Lot-to-lot Consistency of a Plant-Derived Quadrivalent Virus-Like Particles Influenza Vaccine in Healthy Adults
|
Phase 3 | |
Completed |
NCT04644484 -
A Phase III Clinical Study to Evaluate SYN023's Efficacy and Safety
|
Phase 3 | |
Completed |
NCT00984945 -
Safety Study of a Plant-based H5 Virus-Like Particles (VLP) Vaccine in Healthy Adults
|
Phase 1 | |
Completed |
NCT00734175 -
Safety of and Immune Response to Recombinant Live-Attenuated Influenza H6N1 Virus Vaccine Vaccine
|
Phase 1 | |
Completed |
NCT00516035 -
Single Group Study of the Safety of and Immune Response to a Bird Flu Vaccine (H7N3) in Healthy Adults
|
Phase 1 | |
Active, not recruiting |
NCT05284097 -
Ad26.ZEBOV, MVA-BN-Filo Vaccination in Children and Adults Previously Vaccinated With Control in the EBOVAC-Salone Study
|
Phase 2 | |
Completed |
NCT03739112 -
Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly
|
Phase 3 | |
Recruiting |
NCT06113757 -
Investigation of Efficacy and Safety of Electrical Signal Therapy Provided by Dr Biolyse® Device in COVID-19 Disease
|
N/A | |
Completed |
NCT01991587 -
Safety, Tolerability and Immunogenicity of a Plant-made Seasonal Quadrivalent VLP Influenza Vaccine in Adults
|
Phase 1/Phase 2 | |
Completed |
NCT03294135 -
The Aim of This Study is to Investigate the Persistence of Antibody Response in Adults up to 15 Years After One Booster Dose of GlaxoSmithKline (GSK) Biologicals' Encepur Adults Vaccine
|
Phase 4 | |
Active, not recruiting |
NCT02545517 -
A Clinical Study to Evaluate Immune Responses to Rabies Vaccine in Adults Who Received Different Primary Rabies Vaccination Regimens
|
Phase 3 | |
Active, not recruiting |
NCT05619770 -
Study to Evaluate Pharmacokinetics, Safety & Tolerability of 101-PGC-005 in Healthy, Adult, Human Subjects
|
Phase 1 | |
Not yet recruiting |
NCT01289301 -
Studying the Effect of Changing Immunosuppression in Case of Polyoma BK Virus Infection of the Renal Transplant
|
Phase 4 | |
Active, not recruiting |
NCT01055990 -
Basic and Clinical Research on Applying Blood Fix to Treat Critical H1N1 Patients
|
Phase 2 | |
Completed |
NCT00980447 -
Immunogenicity, Safety and Optimal Dose Finding Study of Recombinant Influenza H5N1 Vaccine in Healthy Young Adults
|
Phase 2 | |
Completed |
NCT01842997 -
Safety of H1N1 Influenza Vaccination in Pregnant Women
|
Phase 4 | |
Completed |
NCT00380237 -
Safety of and Immune Response to a Bird Flu Virus Vaccine (H9N2) in Healthy Adults (Study B)
|
Phase 1 | |
Completed |
NCT00219453 -
Pilot Safety Study to Determine the Ability of the Protector Cap Jet Injector to Prevent Cross-Contamination
|
Phase 1 | |
Completed |
NCT02548078 -
A Study to Evaluate the Safety and Immunogenicity of a Candidate Ebola Vaccine in Children
|
Phase 2 |