Third Party Viral Specific T-cells (VSTs)

Status Recruiting

Clinical Trial Summary

The purpose of this study is to demonstrate that viral specific T-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.

Clinical Trial Description

Viral reactivation and infection is a major cause of morbidity in immunocompromised patients (including HSCT recipients). In this study we will draw blood from unrelated (third party) donors and use the blood to generate viral specific T-cells (VSTs) with specificity for Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (ADV), BK virus (BKV), and JC Virus. The VSTs will be infused into immunocompromised children with specific viral infections (EBV, CMV, ADV, BKV , or JC virus). Cells will be selected for infusion based on the recipient's HLA type and the viral specificity of the cells. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02532452
Study type	Interventional
Source	Children's Hospital Medical Center, Cincinnati
Contact	Jamie Wilhelm
Phone	(513) 803-1102
Email	Jamie.Wilhelm@cchmc.org
Status	Recruiting
Phase	Phase 2
Start date	September 2, 2015
Completion date	December 2027

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