HIV Clinical Trial
Official title:
Women-Focused HIV Prevention in the Western Cape
The purpose of this study is to test the effectiveness of a woman-focused HIV prevention intervention combined with voluntary counseling and testing (VCT), compared to VCT only, and VCT combined with an attention-control nutrition intervention.
Surveillance data indicate that HIV risk and substance use is a serious problem among South
African women. This study, funded by the National Institute on Child Health and Human
Development (NICHD), builds on findings from a recently completed pilot study among women in
less affluent townships and communities in the Western Cape (Wechsberg et al., 2008). The
pilot study tested the effectiveness of an evidence-based woman-focused intervention in
reducing drug use, sexual risk, and victimization by addressing the intersection of these
factors among 100 poor, substance-using women of colour.
The primary aim of this study is to test the effectiveness, through a randomized controlled
trial (RCT), of VCT plus a woman-focused intervention relative to VCT only to increase
knowledge and skills to reduce substance abuse, sexual risk, and victimization, and to an
equal-attention (nutrition) control group at 3-, 6-, 9-, and 12-month follow-ups. A
secondary aim is to examine the moderating effect of victimization (i.e., sexual and
physical) and the mediating effects of HIV risk knowledge, condom use skills, sexual
negotiation assertiveness, and relationship power on the effectiveness of the woman-focused
groups to decrease risk related to drug use, sexual risk, and sex-related-victimization
relative to the rapid testing group and to the equal-attention control group.
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