Vestibular Schwannoma Clinical Trial
Official title:
Recovery of Visual Acuity in Vestibular Deficits
The purpose of this study is to determine whether exercises relieve the symptoms of dizziness and imbalance in people with vestibular deficits and improves the ability to see clearly during head movements. We hypothesize that the performance of specific adaptation and substitution exercises will result in an improvement in visual acuity during head movements while those patients performing placebo exercises will show no improvement.
Decrements in visual acuity during head movement in patients with vestibular hypofunction
are potentially serious problems. This deficit could contribute to decreased activity level,
avoidance of driving with resultant diminished independence and, ultimately, limited social
interactions and increased isolation. Oscillopsia occurs because of inadequate
vestibulo-ocular reflex (VOR) gain and suggests that compensation for the vestibular loss
has not occurred. The purpose of this study was to examine the effect of an exercise
intervention on visual acuity during head movement in patients with unilateral and bilateral
vestibular hypofunction. We hypothesized that 1) patients performing vestibular exercises
would have improved visual acuity during head movement compared to patients performing
placebo exercises; 2) there would be no correlation between dynamic visual acuity (DVA) and
the patients' subjective complaints of oscillopsia; and 3) improvement in DVA would be
reflected by changes in residual vestibular function as indicated by an increase in VOR
gain.
Patients are assigned randomly to either the vestibular exercise or placebo exercise group.
The randomization schedule is generated using a computer program for 2-sample randomization.
The sequence was not concealed from the investigator who obtained consent from the subjects
and supervised the exercises (SJH). The group assignment (vestibular exercise or placebo
exercise) was concealed from the participants and from the investigator who performed the
outcome measures.
The vestibular exercise group practiced exercises that consisted of adaptation exercises and
eye-head exercises to targets (Table 1), which were designed to improve gaze stability 16.
They also performed gait and balance exercises. The placebo exercise group performed
exercises designed to be 'vestibular-neutral'.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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