The Role Of Vestibular Rehabilitation Therapy In Management Of Vestibular Migraine Patients

Vestibular Migraine Clinical Trial

Official title: The Role Of Vestibular Rehabilitation Therapy In Management Of Vestibular Migraine Patients

Status Not yet recruiting

Clinical Trial Summary

1. To assess the criteria of positional vertigo in vestibular migraine patients

2. To assess the effect of vestibular rehabilitation therapy in management of positional vertigo in vestibular migraine patients

Clinical Trial Description

Vestibular migraine(VM) is a variant of migraine where the patient reports recurrent vertigo lasting minutes to days. The migraine headache component may be present with associated light and sound sensitivity but the vestibular symptoms are usually prominent . Migraine prophylaxis has been shown to provide some benefit to help to prevent or abort acute attacks of vertigo .

Vestibular migraine has a life time prevalence of about 1 % and a 1-year prevalence of 0.9 % in the general population and accounts for about 7% of patients seen in dizziness clinics and 9 % of patients seen in migraine clinics .

The International Headache Society and the International Barany Society for Neuro-otology have developed a consensus document with diagnostic criteria for VM . This diagnosis was included in the appendix of the new international classification of headache disorders (ICHD)-3 beta version of headache classification .

Diagnostic criteria The criteria for VM combine the typical signs and symptoms of migraine with the exclusion criteria of other disorders that also elicit vestibular signs . As in migraine without aura, a diagnosis of VM mainly depends on the patient history, for so far there are no clinically useful biomarkers.

Vestibular migraine diagnostic criteria International Bárány Society for Neuro-Otology and the International Headache Society (2012):- A. At least five episodes fulfilling criteria C and D B. A current or past history of migraine without aura or migraine with aura C. Vestibular symptoms of moderate or severe intensity, lasting 5 min to 72 hours D. At least 50 % of episodes are associated with at least one of the following three migrainous features

• Headache with at least two of the following four characteristics

• Unilateral location

• Pulsating quality

• Moderate or severe intensity

• Aggravation by routine physical activity

• Photophobia and phonophobia

• Visual aura The mechanisms underlying vestibular dysfunction that are related to migraine still need further study and clarification. One explanation proposed is a parallel activation of vestibular and cranial nociceptive pathways.

Experimental studies have demonstrated that trigeminal and vestibular ganglion cells share neurochemical properties and express serotonin, capsaicin, and purinergic receptors. Nociceptive and vestibular afferents with neurochemical similarities converge in brainstem structures like the parabrachial nucleus, the raphe nuclei, and the locus coeruleus. All of these structures play an important role in modulating the sensitivity of pain pathways.

The vestibular rehabilitation become one of the main treatment modalities for patients suffering from vestibular dysfunction, patients are referred for vestibular rehabilitation therapy with aim of helping to relieve them of symptoms of dizziness ,gaze instability, disequilibrium and to improve their functional status. ;

Related Conditions & MeSH terms

• Migraine Disorders
• Vestibular Migraine

• NCT number: NCT05508139
• Study type: Observational
• Source: Assiut University
• Contact: Abdelmawla kassem
• Phone: 01019319054
• Email: Abelmawla.Hammad@aun.edu.eg
• Status: Not yet recruiting
• Start date: December 1, 2022
• Completion date: October 2024