Nausea Clinical Trial
Official title:
Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo
- Vertigo complaint is one of the common cause of patients who applied to emergency
services.
- Patients who have applied to emergency services with vertigo complaint mostly have
nausea as an additionally symptom to this complaint and anti-emetic agents can be used
in their treatments very often.
- The investigators purpose is to investigate the advantages of Dimenhydrinate and
metoclopramide to each other in the treatment of vertigo and the vertigo accompanied by
nausea
- Vertigo describes the illusion of being subject to an involuntary movement, usually
rotational, of the patient or the patient's surroundings which is caused by sudden
tonic neural activity.
- The management and episodic treatment of patients with spontaneous vertigo related
nausea-vomiting symptoms are somewhat controversial in the emergency department
setting.
- Patients admitted to the emergency department with complaints of vertigo in addition to
a large portion of the symptoms are accompanied by nausea and antiemetic agents are
frequently used in the treatment.
- An ideal treatment should be rapid in onset and effective, and lack debilitating side
effects.
- Although a wide variety of classes of pharmacologic agents and modalities are used, the
emergency department treatment of acute spontaneous vertigo and associated with nausea-
vomiting has not been well studied.
- It has been reported that the most commonly used medications for parenteral treatment
of vertigo and nausea-vomiting in emergency department are dimenhydrinate (DMT) and
metoclopramide (MTP).
- It has a depressant action on hyper-stimulated labyrinthine function and antiemetic
effects, believed to be due to the antihistamine.
- Dimenhydrinate inhibits vomiting by affecting the histaminic receptor and cholinergic
receptor function center of vestibular nucleus in the central vestibular system.
- Dimenhydrinate reduces the symptoms of vertigo with depressant effects on the labyrinth
function by this means.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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