Thiol/Disulphide Homeostasis and Albumin in Vertigo

Oxidative Stress Clinical Trial

Official title: Evaluation of Thiol/Disulfide Homeostasis and Ischemia Modified Albumin Levels in the Differential Diagnosis of Central and Peripheral Vertigo

Status Completed

Clinical Trial Summary

Vertigo is a common complaint in the Emergency Department (ED). The differential diagnosis of central and peripheral vertigo is a difficult issue that directly affects mortality. Magnetic resonance imaging (MRI) is the preferred diagnostic tool, but may not be suitable in all patients due to logistic and economic conditions. In this study, the investigators evaluated the role of thiol/disulfide homeostasis (TDH) parameters and ischemia modified albumin (IMA) levels to assist in the value of being used instead of MRI.

Clinical Trial Description

The study was conducted in the ED using a prospective, non-randomized method, and included patients with complaints of acute onset vertigo over 18 years of age and who underwent brain MRI. Pregnant women, smokers, and those with significant neurological signs were excluded. Patients with acute ischemia with MRI were included in the central vertigo group, and patients with normal MRI were included in the peripheral vertigo group. Blood samples for native thiol (NT), total thiol (TT), disulfide, and IMA were collected from all patients at admission. Statistical analyzes were performed with IBM SPSS Statistics for Windows 16.0 Package Program. ;

Related Conditions & MeSH terms

• Diagnosis
• Dizziness
• Oxidative Stress
• Vertigo
• Vertigo, Central Origin
• Vertigo, Peripheral

• NCT number: NCT04070664
• Study type: Observational
• Source: Ankara City Hospital Bilkent
• Status: Completed
• Start date: July 1, 2018
• Completion date: December 31, 2018