Clinical Trials Logo
  1. Home
  2. Ventricular Tachycardia
  3. NCT05377216
  4. Details
NCT05377216 Clinical Trial

Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation

Ventricular Tachycardia Clinical Trial

Official title:
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05377216
Other study ID # 851066
Secondary ID
Status Recruiting
Phase Early Phase 1
First received
Last updated
Start date September 1, 2022
Est. completion date July 1, 2027

Study information
Verified date October 2023
Source University of Pennsylvania
Contact Timothy Markman, MD
Phone 267-593-0103
Email timothy.markman@pennmedicine.upenn.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Prospective cohort study evaluating the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia.

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date July 1, 2027
Est. primary completion date June 30, 2027
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Planned catheter based VT ablation - Age at least 18 years Exclusion Criteria: - Pregnancy - Contraindication to SGB or VT ablation - Hypersensitivity of local anesthetic of amide type - Hemodynamic instability during the procedure prior to the study protocol

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Stellate Ganglion Block
Left sided percutaneous stellate ganglion block

Locations
Country Name City State
United States Hospital of the University of Pennsylvania Philadelphia Pennsylvania

Sponsors (1)
Lead Sponsor Collaborator
University of Pennsylvania

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Ventricular Effective Refractory Period Change in Ventricular Effective Refractory Period at 600ms drive train (measured in milliseconds) 30 minutes following stellate ganglion block
Secondary Ventricular Arrhythmia Inducibility Induction of monomorphic ventricular arrhythmia (binary outcome) during ventricular programmed stimulation 30 minutes following stellate ganglion block
Secondary Neuropeptide Y Change in level of neuropeptide Y from baseline (measured in pg/mL) 30 minutes following stellate ganglion block
See also
  Status Clinical Trial Phase
Recruiting NCT03453645 - Modification of Rhythmic Risk Assessment by Ventricular Tachycardia Ablation
Completed NCT05791032 - Sub Chronic Evaluation for ATP With an Extravascular Placed ICD Lead (STEP ICD) Study N/A
Completed NCT05970120 - A Study of Intracardiac Ultrasound With the NUVISION NAV Ultrasound Catheter N/A
Completed NCT04011631 - Evaluation of the iD-SystemTM, One-Handed Disposable Internal Defibrillation System. N/A
Recruiting NCT03536052 - Ablation at Virtual-hEart pRedicted Targets for VT N/A
Not yet recruiting NCT06063811 - Ventricular Tachycardia Ablation in LVAD Patients
Enrolling by invitation NCT02962076 - Study of Cardiac PET/CT Imaging to Guide Ablation Treatment of Ventricular Tachycardia Early Phase 1
Not yet recruiting NCT02784912 - Biomarkers in Risk Stratification of Sustainted Ventricular Tachycardia or Electrical Storm After Ablation N/A
Completed NCT01791543 - Intramural Needle Ablation for Ablation of Recurrent Ventricular Tachycardia N/A
Terminated NCT02891863 - Low Energy Therapy to Convert Ventricular Tachycardias Phase 0
Terminated NCT01546207 - Stepwise Approach To sUbstrate Modification for Ventricular Tachycardia N/A
Completed NCT01294267 - Percutaneous Hemodynamic Support With Impella 2.5 During Scar-related Ventricular Tachycardia Ablation N/A
Terminated NCT00383799 - Iv Amiodarone Versus Iv Procainamide to Treat Haemodynamically Well Tolerated Ventricular Tachycardia Phase 4
Completed NCT04884100 - enHEART - Exploring Full Content of Optical Signals to Enhance Cardiac Arrhythmia Screening N/A
Completed NCT04642963 - Stereotactic Management of Arrhythmia - Radiosurgery in Treatment of Ventricular Tachycardia N/A
Not yet recruiting NCT04990089 - VIVO European Observational Registry
Completed NCT04065893 - Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
Recruiting NCT03631303 - Post-Extrasystolic Potentiation as a Predictor of Ventricular Arrhythmias
Recruiting NCT03611465 - Creation of a Pace-mapping Atlas on Healthy and Pathological Hearts N/A
Suspended NCT05478213 - Ventricular Tachycardia Mechanisms N/A