Modification of Rhythmic Risk Assessment by Ventricular Tachycardia Ablation

Ventricular Tachycardia Clinical Trial

Official title:

Modification of Rhythmic Risk Assessment by Ventricular Tachycardia Ablation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03453645
• Other study ID #: RC31/17/0066
• Secondary ID: 2017-A00582-51
• Status: Recruiting
• Start date: September 9, 2017
• Est. completion date: February 2019

Study information

• Verified date: July 2018
• Source: University Hospital, Toulouse
• Contact: Philippe MAURY, MD
• Phone: 05 61 32 31 00
• Email: maury.p[@]chu-toulouse.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Sudden cardiac death is a frequent cause of cardiovascular mortality. Numerous rhythmic risk assessment criterion have been described targeting the substratum, the cardiac nervous tone or the trigger of arrhythmias. Development of ventricular tachycardia ablation in the past few years show interesting results preventing the recurrence of ventricular arrhythmias.

Description:

Sudden cardiac death is a frequent cause of cardiovascular mortality. Numerous rhythmic risk assessment criterion have been described targeting the substratum, the cardiac nervous tone or the trigger of arrhythmias. Development of ventricular tachycardia ablation in the past few years show interesting results preventing the recurrence of ventricular arrhythmias.

Rhythmic risk assessment criterions have never been studied in relation with ventricular tachycardia ablation. The purpose of this study is to explore the modifications of these criterions after ventricular tachycardia ablation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: February 2019
• Est. primary completion date: September 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients undergoing ventricular tachycardia,

• patients with ischemic cardiomyopathy according to European Society of Cardiology Guidelines,

• patients with implanted cardiac defibrillator.

Exclusion Criteria:

• Contra-indication to stress test,

• permanent atrial fibrillation,

• permanent ventricular pacing,

• left bundle block.

Related Conditions & MeSH terms

• Tachycardia
• Tachycardia, Ventricular
• Ventricular Tachycardia

Intervention

Procedure:
• ventricular tachycardia ablation
The usual organization of hospitalization of the patients addressed for ventricular tachycardia ablation and his follow-up are not modified by the protocol. .

Locations

Country	Name	City	State
France	University Hospital of Toulouse	Toulouse

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Toulouse

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	measure assessing change before and after Ventricular Tachycardia Ablation of the non-invasive parameters analysis of the rhythmic risk before and after Ventricular Tachycardia Ablation	non invasive parameters analysis of the rhythmic risk will be evaluated by the evaluation of the T wave alternans	10 minutes and 60 minutes after the Ventricular Tachycardia Ablation
Secondary	Assessing the correlations of the modifications of the risk criterion after ablation with the recurrences of arrhythmias at one year follow-up	the recurrences of arrhythmias will be evaluated . There will be assessed by the informations reveled by the Implantable automatic defibrillator	3 months, 6 months and 12 months after the Ventricular Tachycardia Ablation
Secondary	Study of the correlation between the modifications of non-invasive parameters analysis of the rhythmic risk and the success of the ablation procedure	Success of the ablation procedure is defined by the absence of inducible Ventricular Tachycardia at the end of the procedure.	3 months, 6 months and 12 months after the Ventricular Tachycardia Ablation