Diagnostic Modalities for VAP Detection

Status Completed

Clinical Trial Summary

asses diagnostic performance of different methods for detection of ventilator associated pneumonia.

Clinical Trial Description

Ventilator associated pneumonia (VAP) is a common cause of nosocomial infection, that can complicate mechanical ventilation and is related to significant utilization of health-care resources. The diagnosis of VAP is subjected to considerable interobserver variability. The Centers for Disease Control and Prevention (CDC) definition of VAP uses a combination of clinical, radiographic, and micro-biological criteria for diagnosis, but in the absence of a definite diagnostic test, the accurate diagnosis and treatment of VAP is limited. The clinical pulmonary infection score (CPIS) was developed to objectively diagnose VAP and assign points on the basis of clinical and radiographic data, but its role in diagnosing pneumonia remains controversial . Lung ultrasound (LUS) is a simple, non irradiating, noninvasive, cost-effective, bedside technique. It has been successfully applied for monitoring aeration and monitoring antibiotic efficacy in ventilator-associated pneumonia (VAP). However, no scientific evidence is yet available on whether LUS reliably improves the diagnosis of VAP. Quantitative bacterial cultures of the specimen obtained from the lower airways using bronchoscope were proposed for VAP diagnosis with a cut off value of 104 colony-forming unit/ml. However, microbiological cultures cannot guide the early clinical management of patients with a suspected VAP, as they need at least 24 hours for preliminary results. So, starting antibiotics remains a challenge. Moreover, bronchoscopy is not always easy to perform in hypoxemic patients and not promptly available in all ICUs. Therefore, it can be replaced by tracheal aspirate microbiological samples. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04911244
Study type	Interventional
Source	Assiut University
Contact
Status	Completed
Phase	N/A
Start date	August 2016
Completion date	February 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03937947` - Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study
Not yet recruiting	`NCT04057625` - Transthoracic Ultrasound in the Diagnosis and Follow-up of Ventilator Associated Pneumonia	N/A
Not yet recruiting	`NCT03267693` - Gastrointestinal Complications in Association With Oropharyngeal and Respiratory Infections in Mechanical Ventilation	N/A
Completed	`NCT02078999` - Biomarkers in Patients Undergoing Mechanical Ventilation	N/A
Completed	`NCT00726167` - Serum Procalcitonin Study in the Management of Ventilated Patients	N/A
Recruiting	`NCT05124977` - Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive Care	N/A
Recruiting	`NCT05331885` - A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2	Phase 3
Completed	`NCT05517759` - Application of VAP Bundle Among ICU Nurses
Active, not recruiting	`NCT04488510` - Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia:
Completed	`NCT03917888` - Clinical Impact of Lung Ultrasound Monitoring for Diagnosis of VAP	N/A
Not yet recruiting	`NCT06066489` - Effect of Educational Program About Preventive Care Bundle for Prevention of Ventilator Associated Pneumonia Among Newborns	N/A
Completed	`NCT02096328` - Pharmacokinetics, Safety and Efficacy of POL7080 in Patients With Ventilator Associated Pseudomonas Aeruginosa Pneumonia	Phase 2
Terminated	`NCT00771719` - Open Label Pharmacokinetic in Adult Patients With Ventilator-Associated Pneumonia	Phase 1
Recruiting	`NCT05696093` - Efficacy of Cotrimoxazole as a De-escalation Treatment of Ventilator-Associated Pneumonia in Intensive Care Unit	Phase 3
Recruiting	`NCT05354778` - HYDROcortisone Versus Placebo for Severe HospItal-acquired Pneumonia in Intensive Care Patients: the HYDRO-SHIP Study	N/A
Not yet recruiting	`NCT06059040` - Effect of Eliminating Gastric Residual Volume Monitoring on Ventilator Associated Events	N/A
Completed	`NCT04563104` - Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia
Terminated	`NCT01975350` - Efficacy Study of Colistimethate Sodium Inhalation in Patients With Ventilator-associated Pneumonia
Recruiting	`NCT06000761` - Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care Unit	N/A
Not yet recruiting	`NCT03294837` - Treatment of Ventilator Associated Pneumonia in Pediatric Intensive Care Unit	N/A