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NCT04563104 Clinical Trial

Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia

Ventilator Associated Pneumonia Clinical Trial

Official title:
Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04563104
Other study ID # R 49 / 2020
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 1, 2020
Est. completion date September 1, 2021

Study information
Verified date September 2020
Source Ain Shams University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Ventilator Associated pneumonia (VAP) is associated with longer ICU length of stay, prolonged mechanical ventilation, and increased use of antimicrobials, health-care cost and mortality . Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections, including bacterial infections, viral infections, and infections of other etiologies. Early initiation of adequate antibiotic therapy is the cornerstone in the treatment. However, overuse of antibiotics and prolonged duration of antibiotic therapy in patients with bacterial ARIs in the hospital and intensive care setting is associated with increased resistance for common bacteria, high costs, and adverse drug reactions.

Recruitment information / eligibility
Status Completed
Enrollment 62
Est. completion date September 1, 2021
Est. primary completion date August 1, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - 18 years old or greater - Ventilator associated pneumonia (VAP) with positive sputum culture. Exclusion Criteria: - pregnancy, - use of immunosuppressive agents except for steroids, - neutropenia (white blood cell count =1000/mL) - patients whose primary diagnosis was community acquired pneumonia and other source of infection.

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Lung Ultrasound
We will evaluate the role of lung ultrasound on the duration of antibiotics, we hypothesize that ultrasound imaging may have a role, will be correlated with, procalcitonin (PCT). The created database will help in establishing conclusion and recommendations that will help to improve the antibiotics duration and decrease the resistance.

Locations
Country Name City State
Egypt Ain Shams University Cairo

Sponsors (1)
Lead Sponsor Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary correlation between lung ultrasound and procalcitonin. 7 days
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