Antimicrobial Stewardship Program and Ventilator Associated Pneumonia

Ventilator Associated Pneumonia Clinical Trial

Official title:

Impact of Implementation of Antimicrobial Stewardship Comprehensive Care Bundle Program on Ventilator Associated Pneumonia in Surgical Intensive Care Unit

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04097899
• Other study ID #: 2143/11-5-2015
• Status: Completed
• Start date: July 1, 2016
• Est. completion date: December 31, 2017

Study information

• Verified date: September 2019
• Source: Zagazig University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Antibiotic Stewardship Programs (ASPs) help clinicians improve the quality of patient care and improve patient safety through increased infection cure rates, reduced treatment failures; however, there are different techniques, with variable results, of its application including what is called ASPs bundle and there is a need to investigate the effectiveness of implementing a comprehensive care bundle program including the key components of ASPs and the key items of infection control measures, this program can be called Antimicrobial Stewardship Comprehensive Care Bundle Program (ASCCBP).

Description:

Survey experimental study will be done in the first 6 months as regard antimicrobial drugs pattern and organism's sensitivity and resistance pattern in VAP patients.

In the next six months, clinical implementation of ASPs and infection control bundle will be applied on VAP patients. Then, in the later six months the investigators will study the outcome of VAP patients as regard:

• Amount of cost of antibiotics.

• Appropriates of antibiotic use (initiation, duration & time of discontinuation).

• Rate of resistance

• Clinical outcome, infection rate &length of stay.

Regular reports on antibiotic use and resistance will be admitted to relevant staff every one month. Also, audit and feedback about resistance and optimal prescribing will be applied every one month for ICU stuff as an open discussion.

The stewardship consulting team will include microbiologist with clinical experience in the field of antibiotic use and infection control. Stewardship team also will include the relevant ICU staff and an experienced clinical pharmacist.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: December 31, 2017
• Est. primary completion date: December 31, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients, =18 years, who were intubated and mechanically ventilated for more than 48 hours in ICU and showing clinical criteria of VAP

Exclusion Criteria:

• Patients on immunosuppressive drugs.

• Patient with chronic lung disease, chronic liver disease& chronic renal disease.

• Immunocompromised Patients.

• Patients intubated and mechanical ventilated outside the ICU before admission.

• Patients manifested clinically with picture suggestive of VAP but less than 48 hours on mechanical ventilation.

Related Conditions & MeSH terms

• Pneumonia
• Pneumonia, Ventilator-Associated
• Ventilator Associated Pneumonia

Intervention

Other:
• implementation of antimicrobial stewardship comprehensive care bundle program on ventilator associated pneumonia patients
Construction of a comprehensive care bundle educational program. This program consisted of many elements: Antimicrobial stewardship programs, VAP bundles and infection control policy implementation and the investigators studied the impact of this program on: Antibiotics cost. Appropriates of antibiotic use (initiation, duration & time of discontinuation). Rate of resistance Clinical outcome, infection rate &length of stay.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Zagazig University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in ventilator associated pneumonia incidence	After implementation of the Antimicrobial Stewardship Comprehensive Care Bundle Program (ASCCBP), the percentage of VAP incidence was measured to assess the effectiveness of the program.	18 months
Primary	change in antibiotic resistance pattern	measuring the change in sensitivity and resistance pattern of antibiotics used in ICU was done by assessing the change in the sputum culture and sensitivity results.	18 months
Secondary	ventilation days	Days of mechanical ventilation of each patient were measured to calculate the difference before and after implementation of the program.	18 months
Secondary	antibiotic cost	costs of antibiotics by Egyptian pounds were calculated to assess the effectiveness of the program	18 months