Transthoracic Ultrasound in the Diagnosis and Follow-up of Ventilator Associated Pneumonia

Ventilator Associated Pneumonia Clinical Trial

Official title:

Transthoracic Ultrasound in the Diagnosis and Follow-up of Ventilator Associated Pneumonia

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04057625
• Other study ID #: sonar in vap
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 2019
• Est. completion date: October 2020

Study information

• Verified date: August 2019
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To evaluate the sensitivity, specificity and diagnostic accuracy of bedside transthoracic ultrasound examination in the diagnosis and follow up of ventilator associated pneumonia.

Description:

VAP is the most frequent hospital-acquired infection in intensive care units. Depending on the diagnostic criteria used, its incidence ranges from 5% to 67%. The risk of acquiring VAP is 3% per day during the first 5 days on mechanical ventilation, and it is decreased to 1% per day for the following days.

VAP is suspected when subject shows high grade fever, increase in leukocyte count, change in color of sputum and tachypnea. It's a leading cause of mortality in 15- 65% of the cases.

Serial chest x-ray for diagnosis and follow up, done at time of diagnosis, after 5 days and after 10 days. Chest radiography is consistently carried out after LUS , LUS is done every other day, measuring the largest area of consolidation according to the intercostal space and direction of the probe . Chest radiography is read by two physicians.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 1
• Est. completion date: October 2020
• Est. primary completion date: September 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Mechanical ventilation for at least 48 hours.

• New or evolving infiltrate on chest radiograph (CXR).

• Clinical pulmonary infection score more than or equal 6

Exclusion Criteria:

• Patients who are less than 18 years old.

• Patients who have evidence of pneumonia before or prior to being mechanically ventilated.

• Patients with pulmonary infarction.

Related Conditions & MeSH terms

• Lung Ultrasound
• Pneumonia
• Pneumonia, Ventilator-Associated
• Ventilator Associated Pneumonia

Intervention

Device:
• transthoracic ultrasound
using transthoracic ultrasound in the diagnosis and follow up of vap,measuring the largest area of consolidation according to intercostal space and the direction of the probe.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	detecting ultrasound efficiency in diagnosis and follow up of vap	Sensitivity, specificity, and diagnostic accuracy of lung ultrasound to diagnose and follow up ventilator-associated pneumonia.	baseline
Secondary	icu stay	Duration of stay in ICU.	baseline
Secondary	hospital stay	Duration of hospital stay.	basline
Secondary	mortality	mortality from vap	basline