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The Gravity-VAP (Ventilator-Associated Pneumonia) Trial — Gravity-VAP  

Ventilator Associated Pneumonia Clinical Trial

Official title:
Prospective, Randomized, Multi-Center Trial of Lateral Trendelenburg Versus Semi-Recumbent Body Position in Mechanically Ventilated Patients For The Prevention of Ventilator-Associated Pneumonia

Clinical Trial Summary

This study is planned to compare, in patients sedated, intubated and mechanically ventilated, the efficacy and safety of the Lateral Trendelenburg position in comparison to the Semirecumbent Position to prevent incidence of ventilator-associated pneumonia (VAP).

Clinical Trial Description

This study is planned to compare, in patients sedated, intubated or tracheostomized and mechanically ventilated, the efficacy and safety of two body positions in reducing incidence of ventilator-associated pneumonia. The semi-recumbent position prevents gastro-oropharyngeal aspiration of bacteria laden gastric contents and the "gastro-pulmonary" route of colonization. The lateral-Trendelenburg position aims to promote outward drainage of bacteria-laden oropharyngeal secretion, while avoiding bacterial translocation from the oropharynx into the lungs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01138540
Study type Interventional
Source Policlinico Hospital
Contact
Status Terminated
Phase Phase 3
Start date November 2010
Completion date April 2015
View Details
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