Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05974982 |
Other study ID # |
NO.F.2-81/2022-GENL/249/JPMC |
Secondary ID |
|
Status |
Completed |
Phase |
Phase 1
|
First received |
|
Last updated |
|
Start date |
September 1, 2022 |
Est. completion date |
May 25, 2023 |
Study information
Verified date |
July 2023 |
Source |
Jinnah Postgraduate Medical Centre |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
The use of PRP has dramatically increased in the fields of orthopedics, spine surgery,
reconstructive plastic surgery, oral and maxillofacial surgery, and dermatological
indications. Nonetheless, its use in the treatment of wounds is not as widespread as in other
fields. In this experimental study, the treatment outcome of autologous PRP was assessed in
comparison to conventional therapy among patients with chronic venous leg ulcers.
Description:
Venous ulcers are the most common form of leg ulcers which have a significant impact on
quality of life and work productivity. In addition, the costs associated with the long-term
care of these chronic wounds are substantial. Conventional therapies such as dressings,
surgical debridement, compression bandage, and even skin grafting cannot provide satisfactory
healing since these treatments are not able to provide necessary growth factors that can
modulate healing processes. Autologous platelet-rich plasma (PRP) is a safe, simple,
affordable, and less expensive procedure in the treatment of chronic ulcers with reportedly
good results. Since it is an autologous method, it is biocompatible and safe. Data from this
would help in establishing it as a treatment of choice, thereby leading to a reduction in
cost and benefiting the patient both financially and psychologically.
PRP is a volume of autologous plasma that has a platelet concentration above baseline i.e.,
five times more than normal platelet counts. PRP enhances wound healing by promoting the
healing process by seven growth factors present in it. They are platelet-derived growth
factor (αα, αβ, αβ), fibroblast growth factor, vascular endothelial growth factor, epidermal
growth factor, and transforming growth factor. These growth factors are important in
modulating mesenchymal cell recruitment, proliferation, and extra-cellular matrix synthesis
during the healing process.