Venous Thromboembolism Clinical Trial
Official title:
The Negative Predictive Value of D-dimer on the Risk of Recurrent Venous Thromboembolism in Patients With Multiple Previous Events: a Prospective Cohort Study
Optimal duration of oral anticoagulant therapy in patients with recurrent episodes of venous
thromboembolism (VTE) is a matter of debate and recommendations are based on inadequate
evidence. More than 12 months of treatment are currently recommended, and the grade of
recommendation is low.
The PROLONG study has recently evaluated the predictive role of D-dimer measurement after
withholding oral anticoagulant treatment in patients with a first episode of VTE. Patients
with a positive D-dimer had a significantly higher incidence of VTE recurrences than
patients with a negative D-dimer and required resumption of the antithrombotic treatment.
Based on the results of this and of previous cohort studies, it appears safe to withhold
treatment in patients with negative D-dimer values and to continue treatment in patients
with altered D-dimer levels.
Aim of this study is therefore to assess the negative predictive value of D-dimer also in
patients with recurrent VTE and to evaluate the clinical utility of this approach in this
patient setting.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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