Cognitive Impairment Clinical Trial
Limited treatments are available to improve consciousness in severely brain injured
patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that
showed evidence of efficacy to increase level of consciousness and functional communication
in some minimally conscious state (MCS) patients, and in some vegetative state (VS)
patients. However the optimal intensity of electrical current stimulation remains unknown.
This study will test the effects of two intensities of tDCS stimulation (either 0.2mA or
2mA) applied on left dorso-lateral prefrontal cortex on both behavior, - assessed by the
Coma Recovery Scale-Revised (CRS-R) scores -, as well as quantified EEG recorded during
resting state (using algorithms previously designed and published by the investigators) and
event-related potentials (using auditory paradigms we previously published) in severely
brain damaged patients with disorders of consciousness (MCS, VS, and conscious but
cognitively disabled patients) of various etiologies.
This study will use a cross-over double-blind design with each patient receiving both current intensities in a randomized order during 4 weeks (2 weeks for each tDCS intensity, totalizing a number of 10X2 stimulation sessions of 20 minutes each). ;
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