Minimally Conscious State Clinical Trial
Official title:
Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness: a Sham-controlled Randomised Double Blind Study
Previous studies showed that anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal (DLPF) cortex transiently improves performance of memory and attention. Investigator assessed the effects of left DLPF-tDCS on Coma Recovery Scale-Revised (CRS-R) scores in severely brain damaged patients with disorders of consciousness in a double-blind sham-controlled experimental design.
Following severe brain damage and coma, some patients may remain in a vegetative state (VS)
or minimally conscious state (MCS). At present, there are no evidence-based guidelines
regarding the treatment of patients with disorders of consciousness (DOC).
Investigator aim to assess the effect of single session anodal (i.e., excitatory)
transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex
(DLPF) on the level of consciousness in DOC patients in a double blind randomized sham
controlled study.
tDCS is a form of safe non-invasive cortical stimulation, modulating cortical excitability
at stimulation sites via weak polarizing currents, previously reported to transiently
improve working memory and attention by stimulating the left DLPF in healthy subjects and
patients with stroke, Parkinson's or Alzheimer's disease.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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